RT Journal Article
T1 Burden of postmenopausal breast cancer attributable to excess body weight: comparative study of body mass index and CUN- BAE in MCC- Spain study
A1 Cubelos Fernández, Naiara
A1 Alguacil Ojeda, Juan
A1 Martín, Vicente
AB Background 10% of postmenopausal breast cancer cases are attributed to a high body mass index (BMI). BMI underestimates body fat, particularly in older women, and therefore the cancer burden attributable to obesity may be even higher. However, this is not clear. CUN- BAE (Clínica Universidad de Navarra–Body Adiposity Estimator) is an accurate validated estimator of body fat, taking into account sex and age. The objective of this study was to compare the burden of postmenopausal breast cancer attributable to excess body fat calculated using BMI and CUN- BAE. Methods This case–control study included 1033 cases of breast cancer and 1143 postmenopausal population controls from the multicase–control MCC- Spain study. Logistic regression models were used to calculate odds ratios (ORs). The population attributable fraction (PAF) of excess weight related to breast cancer was estimated with both anthropometric measures. Stratified analyses were carried out for hormone receptor type. Results Excess body weight attributable to the risk of breast cancer was 23.0% when assessed using a BMI value ≥30 kg/m2 and 38.0% when assessed using a CUN- BAE value of ≥40% body fat. Hormone receptor stratification showed that these differences in PAFs were only observed in hormone receptor positive cases, with an estimated burden of 19.9% for BMI and 41.9% for CUN-BAE. Conclusion These findings suggest that the significance of excess body fat in postmenopausal hormone receptor positive breast cancer could be underestimated when assessed using only BMI. Accurate estimation of the cancer burden attributable to obesity is crucial for planning effective prevention initiatives
PB BMJ Publishing Group
SN 0143-005X
SN 1470-2738 (electrónico)
YR 2024
FD 2024-10
LK https://hdl.handle.net/10272/24307
UL https://hdl.handle.net/10272/24307
LA eng
NO Cubelos-Fernández, N., Dávila-Batista, V., Fernández-Villa, T., Castaño-Vinyals, G., Perez-Gomez, B., Amiano, P., Ardanaz, E., Delgado Sillero, I., Llorca, J., Tardón, G. F., Alguacil, J., Vanaclocha Espí, M., Marcos-Gragera, R., Moreno, V., Aragones, N., Dorronsoro, A., Guevara, M., Reguero Celada, S., Pollan, M., … Martín, V. (2024). Burden of postmenopausal breast cancer attributable to excess body weight: comparative study of body mass index and CUN-BAE in MCC-Spain study. In Journal of Epidemiology and Community Health (p. jech-2023-220706). BMJ. https://doi.org/10.1136/jech-2023-220706
NO This research was supported by Acción Transversal del Cáncer (approved by the Spanish Council of Ministers on 11 October 2007), Carlos III Health Institute- FEDER (PI08/1770, PI08/0533, PI08/1359, PS09/00773, PS09/01286, PS09/01903, PS09/02078, PS09/01662, PI11/01403, PI11/01889- FEDER, PI11/00226, PI11/01810, PI11/02213, PI12/00488, PI12/00265, PI12/01270, PI12/00715, PI12/00150, PI14/01219, PI14/0613, PI15/00069, PI15/00914, PI15/01032, PI11/01810, PI14/01219, PI11/02213, PIE16/00049, PI17/01179, PI17/00092), Fundación Marqués de Valdecilla (API 10/09), ICGC International Cancer Genome Consortium CLL (the ICGC CLL- Genome Project is funded by the Spanish Ministry of Economy and Competitiveness through the Carlos III Health Institute (ISCIII)), ISCIII Red Temática de Investigación del Cáncer (RTICC) (RD12/0036/0036), Regional Government of Castilla y León (LE22A10- 2), Regional Health Ministry of Andalucía (PI- 0571- 2009, PI- 0306- 2011, salud201200057018tra), Regional Health Ministry of Valencia (AP_061/10), Recercaixa (2010ACUP00310), Regional Government of the Basque Country, Regional Health Ministry of Murcia, European Commission (grants FOOD-CT-2006–036224-HIWATE), Spanish Association Against Cancer (AECC) Scientific Foundation (GCTRA18022MORE), Agency for Management of University and Research Grants (AGAUR) of the Catalan Regional Government (2014SGR647, 2014SGR850 and 2017SGR723), Fundación Caja de Ahorros de Asturias and University of Oviedo. ISGlobal is a member of the CERCA Program, Regional Government of Catalonia. VD- B is contracted with the competitive national postdoctoral ’Sara Borrell’ fellowship programme (CD21/00025) funded by Instituto de Salud Carlos III (ISCIII) and the European Regional Development Funds/European Social Fund
DS Repositorio Institucional de la Universidad de Huelva
RD 30 may 2026