RT Journal Article
T1 In vitro selenium bioaccessibility combined with in vivo bioavailability and bioactivity in Se-enriched microalga (Chlorella sorokiniana) to be used as functional food
A1 Gómez Jacinto, Verónica
A1 Navarro Roldán, Francisco Juan
A1 Garbayo Nores, Inés
A1 Vílchez Lobato, Carlos
A1 Arias Borrego, Ana
A1 García Barrera, Tamara
AB Speciation of seleno-metabolites and selenoproteins in Se-enriched Chlorella sorokiniana microalgae, in vitro and in vivo extracts has been performed by HPLC-ICP-MS. Selenium bioaccesibility in Se-enriched Chlorela sorokiniana evaluated by in vitro gastrointestinal digestion of the selenized microalga was 81% (79% as SeMet). Mice supplemeted with Se-enriched C. sorokiniana presented increased Se concentration in kidney, reflecting a potencial mechanism of excretion by urine. In addition, selenium bioavailavility, which was in the range of 3–15% depending on the diet was 1.13-fold higher in mice fed with Se-enriched microalgae against the basal diet, but decreased with higher amounts of selenium. Regarding bioactivity (∑Se as selenoproteins in serum/total Se in serum = 76–85% depending on the diet), selenium and selenoproteins (SeP) increased in serum from animals fed high supplemental Se levels. These results showed that Se-enriched algae can be considered as an alternative selenized food for humans, due to their high Se bioavailability.
PB Elsevier
SN 1756-4646
YR 2020
FD 2020-03
LK http://hdl.handle.net/10272/19564
UL http://hdl.handle.net/10272/19564
LA eng
NO Gómez-Jacinto, V., Navarro-Roldán, F., Garbayo-Nores, I., Vílchez-Lobato, C., Borrego, A. A., & García-Barrera, T. (2020). In vitro selenium bioaccessibility combined with in vivo bioavailability and bioactivity in Se-enriched microalga (Chlorella sorokiniana) to be used as functional food. Journal of Functional Foods, 66, 103817. https://doi.org/10.1016/j.jff.2020.103817
NO This work has been supported by the projects CTM2015-67902-C2-1-P and PG2018-096608-B-C21 from the Spanish Ministry of Economy and Competitiveness and P12-FQM-0442 and P09-FQM-04659 from the Regional Ministry of Economy, Innovation, Science and Employment (Andalusian Government, Spain). Finally, authors are grateful to FEDER (European Community) for financial support, grants number UNHU13-1E-1611 and UNHU15-CE-3140.
DS Repositorio Institucional de la Universidad de Huelva
RD 1 jun 2026