RT Journal Article
T1 Insights into cancer and neurodegenerative diseases through selenoproteins and the connection with gut microbiota – current analytical methodologies
A1 Arias Borrego, Ana
A1 Callejón Leblic, María Belén
A1 Calatayud, Marta
A1 Gómez Ariza, José Luis
A1 Collado, Maria Carmen
A1 García Barrera, Tamara
AB Plays many key roles in health especially in connectionwith cancer and neurodegenerative diseases, among others. However, it needsto be appreciated that the essentiality or toxicity action of selenium depends onboth, a narrow range of concentration and the chemical specie involved. In thiscontext, human selenoproteins are essential biomolecules against thesedisorders, mainly due to its antioxidant action. To this end, analyticalmethodologies may allow identifying and quantifying individual selenospecies inhuman biofluids and tissues.Areas covered: This review explores the role of selenoproteins in medicine, withspecial emphasis in cancer and neurodegenerative diseases, considering thepossible link with gut microbiota, and analytical techniques and proceduresrecently developed for the absolute quantification of selenoproteins andselenometabolites in human biofluids and tissues
PB Taylor & Francis
SN 1478-9450
SN 1744-8387 (electrónico)
YR 2019
FD 2019
LK https://hdl.handle.net/10272/23239
UL https://hdl.handle.net/10272/23239
LA eng
NO Arias-Borrego, A., Callejón-Leblic, B., Calatayud, M., Gómez-Ariza, J. L., Collado, M. C., & García-Barrera, T. (2019). Insights into cancer and neurodegenerative diseases through selenoproteins and the connection with gut microbiota – current analytical methodologies. In Expert Review of Proteomics (Vol. 16, Issue 10, pp. 805–814). Informa UK Limited. https://doi.org/10.1080/14789450.2019.1664292
NO Projects CTM2015-67902-C2-1-P and PG2018- 096608-B-C21 from the Spanish Ministry of Economy and Competitiveness (MINECO),and by projects P12-FQM-0442 from the Regional Ministry of Economy, Innovation,Science and Employment (Andalusian Government, Spain). Finally, authors aregrateful to FEDER (European Community) for financial support, Grant UNHU13-1E-1611.
DS Repositorio Institucional de la Universidad de Huelva
RD 31 may 2026