@article{10272/16360,
year = {2018},
month = {12},
url = {http://hdl.handle.net/10272/16360},
abstract = {We report herein the controlled surface functionalization of micro- and nanoparticles by supramolecular
host–guest interactions. Our idea is to exploit the competition of two high-affinity guests for binding to
the surface-bound supramolecular host cucurbit[7]uril (CB7). To establish our strategy, surface azide
groups were introduced to hard-sphere (poly)methylmethacrylate particles with a grafted layer of
poly(acrylic acid), and a propargyl derivative of CB7 was coupled to the surface by click chemistry. The
amount of surface-bound CB7 was quantified with the high-affinity guest aminomethyladamantane
(AMADA), which revealed CB7 surface coverage densities around 0.3 nmol cm 2 indicative of a 3D layer
of CB7 binding sites on the surface. The potential for surface functionalization was demonstrated with an
aminoadamantane-labeled rhodamine (Ada-Rho) as a second high-affinity guest. Simultaneous
incubation of CB7-functionalized particles with both high-affinity guests, AMADA and Ada-Rho, revealed
a simple linear relationship between the resulting surface coverage densities of the model fluorescent
dye and the mole fraction of Ada-Rho in the incubation mixture. This suggests a highly modular
supramolecular strategy for the stable immobilization of application-relevant molecules on particle
surfaces and a precise control of their surface coverage densities.},
organization = {The financial support from the Deutsche Forschungsgemeinschaft (HE 5967/4-1 and NA 686/11-1), the China Scholarship Council (S. Z.), the Ministerio de Economia, Industria y Competitividad, Madrid (grant CTQ2014-54729-C2-1-P and predoctoral contract BES-2015-074458 for Z. D.), and the Ministerio de Ciencia, Innovacion y Universidades, Madrid (grant CTQ2017-89832-P) is gratefully acknowledged.},
publisher = {Royal Society of Chemistry},
title = {Precise supramolecular control of surface coverage densities on polymer micro- and nanoparticles},
doi = {10.1039/c8sc03150a},
author = {Zhang, Shuai and Domínguez, Zoe and Khaleel, Assaf and Nilam, Mohamed and Thiele, Thomas and Pischel, Uwe and Schedler, Uwe},
}