RT Journal Article
T1 Precise supramolecular control of surface coverage densities on polymer micro- and nanoparticles
A1 Zhang, Shuai
A1 Domínguez, Zoe
A1 Khaleel, Assaf
A1 Nilam, Mohamed
A1 Thiele, Thomas
A1 Pischel, Uwe
A1 Schedler, Uwe
AB We report herein the controlled surface functionalization of micro- and nanoparticles by supramolecularhost–guest interactions. Our idea is to exploit the competition of two high-affinity guests for binding tothe surface-bound supramolecular host cucurbit[7]uril (CB7). To establish our strategy, surface azidegroups were introduced to hard-sphere (poly)methylmethacrylate particles with a grafted layer ofpoly(acrylic acid), and a propargyl derivative of CB7 was coupled to the surface by click chemistry. Theamount of surface-bound CB7 was quantified with the high-affinity guest aminomethyladamantane(AMADA), which revealed CB7 surface coverage densities around 0.3 nmol cm 2 indicative of a 3D layerof CB7 binding sites on the surface. The potential for surface functionalization was demonstrated with anaminoadamantane-labeled rhodamine (Ada-Rho) as a second high-affinity guest. Simultaneousincubation of CB7-functionalized particles with both high-affinity guests, AMADA and Ada-Rho, revealeda simple linear relationship between the resulting surface coverage densities of the model fluorescentdye and the mole fraction of Ada-Rho in the incubation mixture. This suggests a highly modularsupramolecular strategy for the stable immobilization of application-relevant molecules on particlesurfaces and a precise control of their surface coverage densities.
PB Royal Society of Chemistry
SN 2041-6520
YR 2018
FD 2018-12
LK http://hdl.handle.net/10272/16360
UL http://hdl.handle.net/10272/16360
LA eng
NO Zhang, S., Domínguez, Z., Assaf, K. I., Nilam, M., Thiele, T., Pischel, U., …Schedler, U.  Precise supramolecular control of surface coverage densities on polymer micro- and nanoparticles. Chemical Science, 9(45), 8575–8581. (2018). DOI: https://doi.org/10.1039/c8sc03150a
NO The financial support from the Deutsche Forschungsgemeinschaft (HE 5967/4-1 and NA 686/11-1), the China Scholarship Council (S. Z.), the Ministerio de Economia, Industria y Competitividad, Madrid (grant CTQ2014-54729-C2-1-P and predoctoral contract BES-2015-074458 for Z. D.), and the Ministerio de Ciencia, Innovacion y Universidades, Madrid (grant CTQ2017-89832-P) is gratefully acknowledged.
DS Repositorio Institucional de la Universidad de Huelva
RD 13 jul 2026