RT Journal Article
T1 Validating a breast cancer score in Spanish women. The MCC-Spain study
A1 Dierssen Sotos, Trinidad
A1 Gómez Acebo, Inés
A1 Palazuelos, Camilo
A1 Bayo Calero, Juan Lucas
A1 Llorca, Javier
AB A breast-risk score, published in 2016, was developed in white-American women using 92 geneticvariants (GRS92), modifiable and non-modifiable risk factors. With the aim of validating the scorein the Spanish population, 1,732 breast cancer cases and 1,910 controls were studied. The GRS92,modifiable and non-modifiable risk factor scores were estimated via logistic regression. SNPs withoutavailable genotyping were simulated as in the aforementioned 2016 study. The full model score wasobtained by combining GRS92, modifiable and non-modifiable risk factor scores. Score performanceswere tested via the area under the ROC curve (AUROC), net reclassification index (NRI) and integrateddiscrimination improvement (IDI). Compared with non-modifiable and modifiable factor scores,GRS92 had higher discrimination power (AUROC: 0.6195, 0.5885 and 0.5214, respectively). Addingthe non-modifiable factor score to GRS92 improved patient classification by 23.6% (NRI = 0.236),while the modifiable factor score only improved it by 7.2%. The full model AUROC reached 0.6244.A simulation study showed the ability of the full model for identifying women at high risk for breastcancer. In conclusion, a model combining genetic and risk factors can be used for stratifying womenby their breast cancer risk, which can be applied to individualizing genetic counseling and screeningrecommendations.
PB Nature Research
SN 2045-2322
YR 2018
FD 2018-02
LK http://hdl.handle.net/10272/16820
UL http://hdl.handle.net/10272/16820
LA eng
NO Dierssen Sotos, T.,  Gómez Acebo, I.,  Palazuelos, C., Bayo Calero, J., Llorca, J. (2108) Validating a breast cancer score in Spanish women. The MCC-Spain study. Scientific Reports| (2018) 8:3036. DOI 10.1038/s41598-018-20832-0
NO The study was partially funded by the "Accion Transversal del Cancer" project, approved by the Spanish Council of Ministers on the 11th October 2007, by the Instituto de Salud Carlos III-FEDER (PI08/1770, PI08/0533, PI08/1359, PI09/00773-Cantabria, PI09/01286-Leon, PI09/01903-Valencia, PI09/02078-Huelva, PI09/01662-Granada, PI11/01403, PI11/01889-FEDER, PI11/00226, PI11/01810, PI11/02213, PI12/00488, PI12/00265, PI12/01270, PI12/00715, PI12/00150, PI14/01219), by the Fundacion Marques de Valdecilla (API 10/09), by the ICGC International Cancer Genome Consortium CLL (The ICGC CLL-Genome Project is funded by Spanish Ministerio de Economia y Competitividad (MINECO) through the Instituto de Salud Carlos III (ISCIII) and Red Tematica de Investigacion del Cancer (RTICC) del ISCIII (RD12/0036/0036)), by the Junta de Castilla y Leon (LE22A10-2), by the Consejeria de Salud of the Junta de Andalucia (2009-S0143), by the Conselleria de Sanitat of the Generalitat Valenciana (AP_061/10), by the Recercaixa (2010ACUP 00310), by the Regional Government of the Basque Country, by the European Commission grants FOOD-CT-2006-036224-HIWATE, by the Spanish Association Against Cancer (AECC) Scientific Foundation and by the Catalan Government DURSI grant 2009SGR1489.
DS Repositorio Institucional de la Universidad de Huelva
RD 30 may 2026