RT Journal Article
T1 Fruits and vegetables intake and gastric cancer risk: A pooled analysis within the Stomach cancer Pooling Project
A1 Ferro, Ana
A1 Rute Costa, Ana
A1 Morais, Samantha
A1 Alguacil Ojeda, Juan
AB A low intake of fruits and vegetables is a risk factor for gastric cancer, although there isuncertainty regarding the magnitude of the associations. In our study, the relationshipbetween fruits and vegetables intake and gastric cancer was assessed, complementing aprevious work on the association betweenconsumption of citrus fruits and gastric cancer.Data from 25 studies (8456 cases and 21 133 controls) with information on fruits and/orvegetables intake were used. A two-stage approach based on random-effects modelswas used to pool study-specific adjusted (sex, age and the main known risk factors forgastric cancer) odds ratios (ORs) and the corresponding 95% confidence intervals (CIs).Exposure-response relations, including linear and nonlinear associations, were modeledusing one- and two-order fractional polynomials. Gastric cancer risk was lower for ahigher intake of fruits (OR: 0.76, 95% CI: 0.64-0.90), noncitrus fruits (OR: 0.86, 95% CI:0.73-1.02), vegetables (OR: 0.68, 95% CI: 0.56-0.84), and fruits and vegetables (OR:0.61, 95% CI: 0.49-0.75); results were consistent across sociodemographic and lifestylescategories, as well as study characteristics. Exposure-response analyses showed anincreasingly protective effect of portions/day of fruits (OR: 0.64, 95% CI: 0.57-0.73 forsix portions), noncitrus fruits (OR: 0.71, 95% CI: 0.61-0.83 for six portions) and vegetables(OR: 0.51, 95% CI: 0.43-0.60 for 10 portions). A protective effect of all fruits, noncitrusfruits and vegetables was confirmed, supporting further dietary recommendationsto decrease the burden of gastric cancer.
PB Wiley
SN 1097-0215
YR 2020
FD 2020-06
LK http://hdl.handle.net/10272/18898
UL http://hdl.handle.net/10272/18898
LA eng
NO Ferro, A., Costa, A. R., Morais, S. ... Alguacil Ojeda, J. (2020). Fruits and vegetables intake and gastric cancer risk: A pooled analysis within the Stomach cancer Pooling Project. International Journal of Cancer. DOI: https://doi.org/10.1002/ijc.33134
NO The authors thank the European Cancer Prevention (ECP) Organiza-tion for providing support for the project meetings. Our study issupported by the Associazione Italiana per la Ricerca sul Cancro(AIRC), Project no. 21378 (Investigator Grant), the Italian Ministry ofHealth (Young Researchers, GR-2011-02347943 to SB) and the ItalianLeague for the Fight against Cancer (LILT). This project was alsosupported by FEDER through the Operational Programme Competi-tiveness and Internationalization and national funding from the Foun-dation for Science and Technology - FCT (Portuguese Ministry ofScience, Technology and Higher Education) under the Unidade deInvestigaç~ao em Epidemiologia - Instituto de Saúde Pública daUniversidade do Porto (EPIUnit) (UIDB/04750/2020). AF (PD/BD/105823/2014) was awarded with an individual scholarship throughnational funding from FCT/MCTES. Individual grants attributed toARC (SFRH/BD/102181/2014) and BP (SFRH/BPD/108751/2015)were funded by the FCT and the“Programa Operacional CapitalHumano”(POCH/FSE). SM was funded under the project“NEON-PC- Neuro-oncological complications of prostate cancer: longitudinalstudy of cognitive decline“(POCI-01-0145-FEDER-032358; Ref.PTDC/SAU-EPI/32358/2017). We also thank all MCC-Spain studycollaborators (CIBERESP, ISCIII, ISGlobal, ICO, University of Huelva,University of Oviedo, University of Cantabria, University of León,Granada, Instituto Salud Pública de Navarra, FISABIO, MurciaRegional Health Authority and collaborators). The funding source hadno role in the study design; collection, analysis and interpretation ofdata; in the writing of the report; and in the decision to submit thearticle for publication.
DS Repositorio Institucional de la Universidad de Huelva
RD 31 may 2026