RT Journal Article
T1 Post-mortem human Alzheimer´s brain metallome depends on Braak stages and brain regions
A1 Parra Martínez, Cecilio
A1 Callejón Leblic, María Belén
A1 Rodrigo Lara, Héctor
A1 Fernández Vega, Iván
A1 Guerrero Márquez, Carmen
A1 Rábano, Alberto
A1 García Barrera, Tamara
AB Limited studies have evaluated the influence of redox-related metals on Alzheimer´s brain. We determined 15 metals in 241 human brain samples obtained from five biobanks. We examined the levels of metals in the frontal cortex (CTX) and the basal ganglia (BG) of Alzheimer´s brains of different stages, ranging from Braak stages I and II to Braak stages V and VI. ICP-MS. Imbalances measured metals in the Alzheimer´s brain metallome of different Braak stages and different regions compared to controls and associations in the other areas were estimated by the Krustall-Wallis Test and Spearman correlations, respectively. The metallomes of brain regions compared to the controls were significantly different for most of the metals in the CTX and BG samples. We observed higher levels of Mn, Cu, Mo, and Se and lower levels of Co in Alzheimer´s CTX compared to the controls and higher levels of V and Cr and lower levels of Co in BG. Different associations were found in the Braak stages compared to the control group in CTX and BG samples. Metals may differ in Braak stages across different human brain regions.
PB Nature Research
SN 2045-2322 (electrónico)
YR 2025
FD 2025
LK https://hdl.handle.net/10272/27351
UL https://hdl.handle.net/10272/27351
LA eng
NO Parra-Martínez, C., Callejón-Leblic, B., Rodrigo-Lara, H. et al. Post-mortem human Alzheimer´s brain metallome depends on Braak stages and brain regions. Sci Rep 15, 20709 (2025). https://doi.org/10.1038/s41598-025-08143-7
DS Repositorio Institucional de la Universidad de Huelva
RD 31 may 2026