RT Journal Article
T1 Elastic Modulus of Woven Bone: Correlation with Evolution of Porosity and X-ray Greyscale
A1 Mora Macías, Juan
A1 García Florencio, Paloma
A1 Pajares Vicente, Antonia
A1 Miranda González, Pedro
A1 Domínguez, Jaime
A1 Reina-Romo, Esther
AB The woven bone created during the healing of bone regeneration processes is characterized as being extremely inhomogeneous and having a variable stiffness that increases with time. Therefore, it is important to study how the mechanical properties of woven bone are dependent on its microarchitecture and especially on its porosity and mineral content. The porosity and the x-ray greyscale of specimens taken from bone transport studies in sheep were assessed by means of ex vivo imaging. Our study demonstrates that the porosity of the woven bone in the distraction area diminishes during the healing process from 73.3% 35 days after surgery to 31.9% 525 days after surgery. In addition, the woven bone's porosity is negatively correlated with its Young's modulus. The x-ray greyscale, was measured as an indicator of the level of mineralization of the woven bone. Greyscale index has been demonstrated to be inversely proportional to porosity and to increase to up to 60-80% of the level in cortical bone. The results of this study may contribute to the development of micromechanical models of woven bone and improvements in in silico modelling.
PB Springer
SN 0090-6964
SN 1573-9686 (electrónico)
YR 2020
FD 2020-01
LK https://hdl.handle.net/10272/23089
UL https://hdl.handle.net/10272/23089
LA eng
NO Mora-Macías, J., García-Florencio, P., Pajares, A., Miranda, P., Domínguez, J., & Reina-Romo, E. (2020). Elastic Modulus of Woven Bone: Correlation with Evolution of Porosity and X-ray Greyscale. In Annals of Biomedical Engineering (Vol. 49, Issue 1, pp. 180–190). Springer Science and Business Media LLC. https://doi.org/10.1007/s10439-020-02529-6
NO The authors gratefully acknowledge the Ministerio de Economía y Competitividad del Gobierno España (Grant Number DPI2017-82501-P) and the Consejería de Innovación, Ciencia y Empleo de la Junta de Andalucía (Grant Numbers P09-TEP-5195 and US-1261691) for research funding.
DS Repositorio Institucional de la Universidad de Huelva
RD 1 jun 2026