RT Journal Article
T1 Excitotoxic lesion of the hippocampus of Wistar rats disrupts the circadian control of the latent inhibition of taste aversion learning
A1 Molero Chamizo, Andrés
AB Previous experiments have shown that changes in the time of day between taste pre-exposure and conditioning prevent the latent inhibition of conditioning taste aversion.The effect of these changes in circadian context between pre-exposure and conditioning onthe magnitude of the learned aversion appears to be similar to the effect of changes inspatial context on this type of learning. To elucidate the brain areas involved in thiscircadian dependence of latent inhibition of conditioning taste aversion, the effect ofexcitotoxic lesions of the hippocampus, a region related to spatial-contextual modulationin this learning process, was analyzed. The latent inhibition of conditioning taste aversionin animals with hippocampal lesions, that were pre-exposed and conditioned to the sameor different time of day, was compared with the response of animals exposed to eitherconditions (“same” or “different”) but had undergone amygdala lesions or sham lesions.The results showed that selective dorsal hippocampus lesion eliminated the circadiandependence of latent inhibition of taste aversion. A change in the time of day between pre-exposure and conditioning did not prevent latent inhibition in animals with hippocampallesions. In contrast, this change prevented latent inhibition in the amygdala-lesioned andsham groups. These findings suggest that the hippocampus contains a selective mechan-ism that modulates the contextual dependency of the latent inhibition of conditioningtaste aversion without interfering with the effect of taste pre-exposure itself. This studymay help to understand the possible common involvement of the hippocampus indifferent types of contextual control of associative learning.
PB Elsevier
SN 0006-8993
SN 1872-6240 (electrónico)
YR 2023
FD 2023
LK https://hdl.handle.net/10272/23736
UL https://hdl.handle.net/10272/23736
LA eng
NO Molero-Chamizo, A. (2013). Excitotoxic lesion of the hippocampus of Wistar rats disrupts the circadian control of the latent inhibition of taste aversion learning. In Brain Research (Vol. 1533, pp. 105–113). Elsevier BV. https://doi.org/10.1016/j.brainres.2013.08.030
NO The research was supported by an MICYT, CICYT Grant BSO2002-01215, Spain. M. Gallo, I. Morón and M.A. Ballesteros contributed in different ways to the performance of the experiments. The author wishes to thank the reviewers for their comments. The author has no conflicts of interest to declare.
DS Repositorio Institucional de la Universidad de Huelva
RD 14 jul 2026