RT Journal Article T1 Impact of Multiple Sclerosis and Its Association with Depression: An Analytical Case-Control Investigation A1 Ruiz Sánchez, Francisco Javier A1 Martins, Rosário A1 Soares, Solete A1 Romero Morales, Carlos A1 López López, Daniel A1 Gómez Salgado, Juan A1 Jiménez Cebrián, Ana María AB Multiple sclerosis (MS) is a neurological, chronic, inflammatory, and progressive disease with musculoskeletal problems and neurodegenerative disorders that causes worsening of the health status of patients. The aim of this study was to determine the level of depression in MS patients compared to a population of healthy subjects. The established sample size was 116 subjects matched with the same age, sex, and body mass index. The subjects were recruited from different multiple sclerosis associations and neurology clinics in different public health areas (case group n = 58) and healthy subjects from the same locality (control group n = 58). The scores and categories of the Beck Depression Inventory (BDI) in its Spanish version were collected. There was a clear statistically significant difference (p < 0.05) in the BDI scores between both groups. As a result, we found that the subjects with MS presented worse results with BDI = 9.52 ± 7.70 points compared to the healthy subjects with a BDI score = 5.03 ± 5.14. Within the BDI categories, there were statistically significant differences (p < 0.001), which were greater for the MS group. Depression is a dangerous factor for MS patients, being a trigger for a poorer quality of life. PB MDPI SN 2227-9032 (electrónico) YR 2022 FD 2022-11 LK https://hdl.handle.net/10272/22082 UL https://hdl.handle.net/10272/22082 LA eng NO Ruiz-Sánchez, F. J., Martins, M.R., Soares, S., Romero-Morales, C., López-López, D., Gómez-Salgado, J., & Jiménez-Cebrián, A. M. (2022). Impact of Multiple Sclerosis and Its Association with Depression: An Analytical Case-Control Investigation. In Healthcare (Vol. 10, Issue 11, p. 2218). MDPI AG. https://doi.org/10.3390/healthcare10112218 DS Repositorio Institucional de la Universidad de Huelva RD 31 may 2026