@article{10272/28207,
year = {2026},
url = {https://hdl.handle.net/10272/28207},
abstract = {The catalytic conversion of CH4 into CH3X compounds has been reported in a few cases, usually involving dehydrogenative processes in which the H atom is lost. Aiming at expanding this limited set of transformations, we have investigated the methane amidation reaction through metal-catalyzed nitrene transfer reactions, a transformation that remains unreported to date for the lightest hydrocarbon. Herein, we describe the use of copper-based catalysts for the direct, nondehydrogenative amidation reaction of methane via a metal-mediated formal nitrene insertion into the C−H bond, a reaction that is also extended to the series of gaseous alkanes. Mechanistic studies, supported by DFT calculations, a microkinetic model, and experimental evidence have led to the proposal of a metallonitrene intermediate responsible for this C−H amidation process via sequential hydrogen abstraction and rebound steps.},
organization = {We thank the Spanish Ministerio de Ciencia e Innovación for grants TED 2021-130077B-100 (PJP), PID2020-113797RB-C21 (PJP, AC), PID2023-146946NB-I00 (PJP), RED2022-134074-T (PJP), CN2022-136079 (MB), PID2021-128188NB-100 (MB), and the Catalan Agency for Research (AGAUR) 021 SGR 00110 (MB). We also thank Universidad de Huelva/CBUA for open access charges.},
publisher = {American Chemical Society},
title = {Methane Catalytic Amidation via a Plausible Copper-Nitrene Intermediate},
doi = {10.1021/jacs.5c22747},
author = {Martínez Laguna, Jonathan and Cholewinska, Anna and Borrego, Elena and Besora, María and Álvarez, María and Caballero Bevia, Ana and Pérez Romero, Pedro José},
}