RT Journal Article
T1 Water as reaction medium for intermolecular C-H alkane functionalization in micellar catalysis
A1 Ávarez, María
A1 Gava, Riccardo
A1 Ramírez Rodríguez, Manuel
A1 Rull, Silvia G.
A1 Pérez Romero, Pedro José
AB A series of alkanes CnH2n+2 have been functionalized in water as the reaction medium, using a silver-basedcatalyst, upon insertion of carbene (CHCO2Et from N2CHCO2Et) groups into their carbon-hydrogen bonds of hexane,cyclohexane or 2-methylbutane, among others. The regioselectivity toward the distinct reaction sites is identical to thatfound in neat alkane, the water-based system allowing the use of a much shorter excess of the hydrocarbon. This is thefirst example of the intermolecular functionalization of alkanes with this strategy in water. The functionalized alkanespartially undergoes a incorporation of a second carbene unit to provide a-(acyloxy)acetates, in an unprecedented tandemreaction of this nature.
PB ACS Catalysis
SN 2155-5435
YR 2017
FD 2017
LK http://hdl.handle.net/10272/16193
UL http://hdl.handle.net/10272/16193
LA eng
NO Álvarez, M., Gava, R., Rodríguez, M. R., Rull, S. G., & Pérez, P. J. (2017). Water as the Reaction Medium for Intermolecular C–H Alkane Functionalization in Micellar Catalysis. ACS Catalysis, 7(5), 3707-3711. https://doi.org/10.1021/acscatal.6b03669
NO Support for this work was provided by the MINECO (Nos. CTQ2014-52769-C03-01 and CTQ2014-62234-EXP). MA, RG., and S.G.R. thank MINECO for FPI fellowships. M.RR thanks MEC for a FPU fellowship.
DS Repositorio Institucional de la Universidad de Huelva
RD 1 jun 2026