RT Journal Article
T1 Trace elements as potential modulators of puberty-induced amelioration of oxidative stress and inflammation in childhood obesity
A1 González Domínguez, Álvaro
A1 Domínguez Riscart, Jesús
A1 Millán Martínez, María
A1 Mateos Bernal, Rosa María
A1 Lechuga Sancho, Alfonso María
A1 González Domínguez, Raúl
AB Although puberty is known to influence obesity progression, the molecularmechanisms underlying the role of sexual maturation in obesity-related complicationsremains largely unexplored. Here, we delve into the impact ofpuberty on the most relevant pathogenic hallmarks of obesity, namely oxidativestress and inflammation, and their association with trace element bloodstatus. To this end, we studied a well-characterized observational cohort comprisingprepubertal (N = 46) and pubertal (N = 48) children with obesity.From all participants, plasma and erythrocyte samples were collected and subjectedto metallomics analysis and determination of classical biomarkers ofoxidative stress and inflammation. Besides the expected raise of sexual hormones,pubertal children displayed better inflammatory and oxidative control,as reflected by lower levels of C-reactive protein and oxidative damagemarkers, as well as improved antioxidant defense. This was in turn accompaniedby a healthier multielemental profile, with increased levels of essentialelements involved in the antioxidant system and metabolic control (metalloproteinscontaining zinc, molybdenum, selenium, and manganese) anddecreased content of potentially deleterious species (total copper, labile freeiron). Therefore, our findings suggest that children with obesity have an exacerbatedinflammatory and oxidative damage at early ages, which could be amelioratedduring pubertal development by the action of trace element-mediatedbuffering mechanisms.
PB Wiley
SN 0951-6433
SN 1872-8081 (electrónico)
YR 2023
FD 2023
LK https://hdl.handle.net/10272/22151
UL https://hdl.handle.net/10272/22151
LA eng
NO González‐Domínguez, Á., Domínguez‐Riscart, J., Millán‐Martínez, M., Mateos‐Bernal, R. M., Lechuga‐Sancho, A. M., & González‐Domínguez, R. (2023). Trace elements as potential modulators of puberty‐induced amelioration of oxidative stress and inflammation in childhood obesity. In BioFactors. Wiley. https://doi.org/10.1002/biof.1946
NO This research was funded by the Spanish Government through Instituto de Salud Carlos III (PI22/01899, PI18/01316). Állvaro González-Domínguez is supported by an intramural grant from the Biomedical Research and Innovation Institute of Cádiz (LII19/16IN-CO24), and Raúl González-Domínguez is recipient of a “Miguel Servet” fellowship funded by Instituto de Salud Carlos III (CP21/00120).
DS Repositorio Institucional de la Universidad de Huelva
RD 2 jun 2026