RT Journal Article
T1 Impact of Antibiotic-Induced Depletion of Gut Microbiota and Selenium Supplementation on Plasma Selenoproteome and Metal Homeostasis in a Mice Model
A1 Callejón Leblic, María Belén
A1 Selma Royo, Marta
A1 Collado, Maria Carmen
A1 Abril, Nieves
A1 García Barrera, Tamara
AB Selenium (Se) is a micronutrient involved in important health functions and it has been suggested to shape gut microbiota. Limited information on Se assimilation by gut microbes and the possible link with selenoproteins are available. For this purpose, conventional and gut microbiota-depleted BALB/c mice were fed a Se-supplemented diet. The absolute quantification of mice plasma selenoproteins was performed for the first time using heteroatom-tagged proteomics. The gut microbiota profile was analyzed by 16S rRNA gene sequencing. Se-supplementation modulated the concentration of the antioxidant glutathione peroxidase and the Se-transporter selenoalbumin as well as the metal homeostasis, being influenced by microbiota disruption, which suggests an intertwined mechanism. Se also modulated microbiota diversity and richness and increased the relative abundance of some health- relevant taxa (e.g., families Christensenellaceae, Ruminococcaceae, and Lactobacillus genus). This study demonstrated the potential beneficial effects of Se on gut microbiota, especially after antibiotic-treatment and the first associations between specific bacteria and plasma selenoproteins.
PB American Chemical Society
SN 0021-8561
SN 1520-5118 (electrónico)
YR 2021
FD 2021
LK https://hdl.handle.net/10272/21856
UL https://hdl.handle.net/10272/21856
LA eng
NO Callejón-Leblic, B., Selma-Royo, M., Collado, M. C., Abril, N., & García-Barrera, T. (2021). Impact of Antibiotic-Induced Depletion of Gut Microbiota and Selenium Supplementation on Plasma Selenoproteome and Metal Homeostasis in a Mice Model. In Journal of Agricultural and Food Chemistry (Vol. 69, Issue 27, pp. 7652–7662). American Chemical Society (ACS). https://doi.org/10.1021/acs.jafc.1c02622
NO Determinación de metales y Selenoproteinas y su interacción con la Microbiota intestinal tras la ingesta de suplementos de selenio y la administración de antibióticos a ratones Mus musculus.
NO This work was supported by the projects PG2018-096608-BC21 from the Spanish Ministry of Science and innovation (MINECO) and UHU-1256905 from the FEDER Andalusian Operative Program 2014−2020 (Ministry of Economy, Knowledge, Business and Universities, Regional Government of Andalusia, Spain). The authors would like to acknowledge thesupportfromTheRamonArecesFoundation(ref. CIVP19A5918). The authors are grateful to FEDER (European Community) for financial support, grant UNHU13-1E1611.Funding for open access charge: Universidad de Huelva / CBUA
DS Repositorio Institucional de la Universidad de Huelva
RD 30 may 2026