RT Journal Article T1 Effectiveness of web-based and mobile-based psychological interventions to prevent perinatal depression: Study protocol for a systematic review and meta-analysis of randomized controlled trials A1 Motrico, Emma A1 Conejo-Cerón, Sonia A1 Martín Gómez, Carmen A1 Gómez Gómez, Irene A1 Fonseca, Ana A1 Moreno-Peral, Patricia AB IntroductionPerinatal depression is one of the most common complications during pregnancy and one year following childbirth. A negative impact on the mental and physical health of women, their children, partners, or significant others has been associated with this disease. Web-based and Mobile-based psychological interventions can reduce the burden of the disease through prevention of new cases of depression. It is crucial to know the effectiveness of these interventions to implement them around the globe. This systematic review and meta-analysis aims to assess the effectiveness of Web-based and Mobile-based psychological interventions to prevent depression during the perinatal period.Method and analysisA systematic review and meta-analysis will adhere to the PRISMA guidelines. Studies will be identified through MEDLINE, PsycINFO, Web of Science, Scopus, CINAHL, CENTRAL, Opengrey, Australian New Zealand Clinical Trial Registry, National Institute for Mental Health Research at the Australian National University, clinicaltrial.gov, beacon.anu.edu.au, and evidencebasedpsychotherapies.org from inception until 31 March 2021. We will also search the reference lists provided in relevant studies and reviews. The selection criteria will be as follows: 1) pregnant women or women who have given birth in the last 12 months and who were non-depressive at baseline; 2) Web-based and Mobile-Based psychological interventions; 3) comparators will be usual care, attention control, waiting list or no intervention; 4) outcomes will be the incidence of new cases of perinatal depression and/or the reduction of depressive symptoms as measured by validated instruments; and 5) the design of the studies will be randomized controlled trials. No restrictions regarding the year or language of publication will be considered. Pooled standardized mean differences and 95% confidence intervals will be calculated. The risk of bias of the studies will be assessed through the Cochrane Collaboration risk of bias 2.0 tool. Heterogeneity and publication bias will be estimated. Sensitivity and sub-group analyses will also be conducted. Random effects meta-regression will be performed.Ethics and disseminationAs a systematic review, ethical approval is not required. The results from this study will be presented at international conferences and disseminated through peer-reviewed publications. Patients and the public will be involved in the dissemination plans. PB Elsevier SN 10.1016/j.invent.2021.100471 SN 2214-7829 (electrónico) YR 2021 FD 2021 LK http://hdl.handle.net/10272/20590 UL http://hdl.handle.net/10272/20590 LA eng NO Motrico, E., Conejo-Cerón, S., Martín-Gómez, C., Gómez-Gómez, I., Fonseca, A., & Moreno-Peral, P. (2021). Effectiveness of web-based and mobile-based psychological interventions to prevent perinatal depression: Study protocol for a systematic review and meta-analysis of randomized controlled trials. In Internet Interventions (Vol. 26, p. 100471). Elsevier BV. https://doi.org/10.1016/j.invent.2021.100471 NO The project is part of the COST Action Riseup-PPD CA 18138 and wassupported by COST under COST Action Riseup-PPD CA18138; also, bythe Spanish Ministry of Health, the Institute of Health Carlos III, and theEuropean Regional Development Fund “Una manera de hacer Europa”by the Prevention and Health Promotion Research Network ‘redIAPP’(RD16/0007). The funders of the study had no role in the study design orthe writing of the protocol. The corresponding author had final re-sponsibility for the decision to submit for publication. DS Repositorio Institucional de la Universidad de Huelva RD 14 jul 2026