RT Journal Article
T1 Metabolomic research on the role of interleukin-4 in Alzheimer’s disease
A1 González Domínguez, Raúl
A1 García Barrera, Tamara
A1 Vitorica, Javier
A1 Gómez Ariza, José Luis
AB Inflammation plays a prominent role in the pathogenesis of Alzheimer’s disease, affecting both brain and the peripheral system. Thus, modulation of inflammation in animal models of this neurodegenerative disorder may be of great interest to elucidate the pathological mechanisms underlying this inflammatory component. To this end, a metabolomic investigation on a triple transgenic mouse model obtained by crossing the APP/PS1 mice with interleukin-4 knockout mice (a model of impaired immune function) was performed for the first time. Serum samples from transgenic mice and wild type animals were analyzed by direct infusion mass spectrometry followed by multivariate statistics in order to identify altered metabolites. Subsequently, metabolic pathway analysis allowed the elucidation of potential pathological mechanisms associated with the development of Alzheimer-type disorders in response to interleukin-4 deficiency, such as impaired homeostasis of histamine, altered metabolism of amino acids (threonine, aspartate and tyrosine), deregulated urea cycle and increased production of eicosanoids. Therefore, this work demonstrates the potential of this triple transgenic model with modulated immunity for the study of pathological mechanisms associated with inflammation in Alzheimer’s disease.
PB Springer Verlag
SN 1573-3882
SN 1573-3890 (electrónico)
YR 2015
FD 2015
LK http://hdl.handle.net/10272/14675
UL http://hdl.handle.net/10272/14675
LA eng
NO González Domínguez, R., García Barrera, T., Vitorica, J., Gómez Ariza, J.L.: "Metabolomic research on the role of interleukin-4 in Alzheimer’s disease". Metabolomics. Vol. 11, n, 5, págs. 1175–1183, (2015). DOI: 10.1007/s11306-015-0773-z
NO This work was supported by the Projects CTM2012-38720-C03-01 from the Ministerio de Ciencia e Innovacion, and projects P012-FQM-0442 and P009-FQM-4659 from the Consejeria de Innovacion, Ciencia y Empresa (Junta de Andalucia). Raul Gonzalez Dominguez thanks the Ministerio de Educacion for a predoctoral scholarship.
DS Repositorio Institucional de la Universidad de Huelva
RD 13 jun 2026