RT Journal Article
T1 Enantio‐ and Diastereoselective Cyclopropanation of 1‐Alkenylboronates : Synthesis of 1‐Boryl‐2,3‐Disubstituted Cyclopropanes
A1 Carreras, Javier
A1 Caballero Bevia, Ana
A1 Pérez Romero, Pedro José
AB A novel, highly enantio- and diastereoselectivesynthesis of 1-boryl-2,3-disubstituted cyclopropanes has beendeveloped by means of the cyclopropanation of alkenylboronateswith ethyl diazoacetate in the presence of catalyticamounts of a chiral copper(I) complex. The products can alsobe directly accessed from alkynes through an operationallysimple, sequential hydroboration–cyclopropanation protocol.The resulting enantioenriched 1-boryl-2,3-disubstituted cyclopropanesare versatile synthetic intermediates that undergofurther transformations at the carbon–boron bond.
PB Wiley
SN 1433-7851
SN 1521-3773 electrónico
YR 2018
FD 2018
LK http://hdl.handle.net/10272/15969
UL http://hdl.handle.net/10272/15969
LA eng
NO Carreras, J., Caballero, A., & Pérez, P. J. (2018). Enantio- and Diastereoselective Cyclopropanation of 1-Alkenylboronates: Synthesis of 1-Boryl-2,3-Disubstituted Cyclopropanes. Angewandte Chemie International Edition, 57(9), 2334-2338. https://doi.org/10.1002/anie.201710415
NO We thank MINECO for financial support (CTQ2014-52769-C03-01-R and Juan de la Cierva fellow for J.C.) and Junta deAndaluc a (P12-FQM-1765). We also thank Riccardo Gavaand Cristina Gonzalez for additional experiments and FranciscoMolina for X-ray diffraction studies.
DS Repositorio Institucional de la Universidad de Huelva
RD 31 may 2026