RT Journal Article
T1 Altered Metal Homeostasis Associates with Inflammation, Oxidative Stress, Impaired Glucose Metabolism, and Dyslipidemia in the Crosstalk between Childhood Obesity and Insulin Resistance
A1 González Domínguez, Álvaro
A1 Millán Martínez, María
A1 Domínguez Riscart, Jesús
A1 Mateos, Rosa María
A1 Lechuga Sancho, Alfonso María
A1 González Domínguez, Raúl
AB Metals are redox-active substances that participate in central biological processes and may beinvolved in a multitude of pathogenic events. However, considering the inconsistencies reported in theliterature, further research is crucial to disentangle the role of metal homeostasis in childhood obesityand comorbidities using well-characterized cohorts and state-of-the-art analytical methods. To this end,we studied an observational population comprising childrenwith obesity and insulin resistance, childrenwith obesity without insulin resistance, and healthy control children. A multi-elemental approach basedon the size-fractionation of metal species was applied to quantify the total content of various essentialand toxic elements in plasma and erythrocyte samples, and to simultaneously investigate the metalfractions conforming the metalloproteome and the labile metal pool. The most important disturbancesin childhood obesity were found to be related to elevated circulating copper levels, decreased content ofplasmatic proteins containing chromium, cobalt, iron, manganese, molybdenum, selenium, and zinc, aswell as the sequestration of copper, iron, and selenium within erythrocytes. Interestingly, these metaldisturbances were normally exacerbated among children with concomitant insulin resistance, and inturn were associated to other characteristic pathogenic events, such as inflammation, oxidative stress,abnormal glucose metabolism, and dyslipidemia. Therefore, this study represents one-step furthertowards a better understanding of the involvement of metals in the crosstalk between childhood obesityand insulin resistance.
PB MDPI
SN 2076-3921 (electrónico)
YR 2022
FD 2022
LK https://hdl.handle.net/10272/22269
UL https://hdl.handle.net/10272/22269
LA eng
NO González-Domínguez Á, Millán-Martínez M, Domínguez-Riscart J, Mateos RM, Lechuga-Sancho AM, González-Domínguez R. Altered Metal Homeostasis Associates with Inflammation, Oxidative Stress, Impaired Glucose Metabolism, and Dyslipidemia in the Crosstalk between Childhood Obesity and Insulin Resistance. Antioxidants. 2022; 11(12):2439. https://doi.org/10.3390/antiox11122439
NO This research was partially funded by the Spanish Government through Instituto deSalud Carlos III (CP21/00120, PI18/01316). Á.G.-D. is supported by an intramural grant from theBiomedical Research and Innovation Institute of Cádiz (LII19/16IN-CO24), and R.G.-D. is recipientof a “Miguel Servet” fellowship (CP21/00120) funded by Instituto de Salud Carlos III.
DS Repositorio Institucional de la Universidad de Huelva
RD 30 may 2026