RT Journal Article
T1 Bad Prognosis in Critical Ill Patients with COVID-19 during Short-Term ICU Stay regarding Vitamin D Levels
A1 Herrera Quintana, Lourdes
A1 Gamarra Morales, Yenifer
A1 Vázquez Lorente, Héctor
A1 Molina López, Jorge
A1 Castaño Pérez, José
A1 Machado Casas, Juan Francisco
A1 Coca Zúñiga, Ramón
A1 Pérez Villares, José Miguel
A1 Planells, Elena
AB Background and aims: Vitamin D inadequacy may be involved in the mechanisms ofSARS-CoV-2 infection and in potential risk factors for disease propagation or control of coronavirusdisease 2019 (COVID-19). This study assessed a short-term evolution of vitamin D status and itsinfluence upon different clinical parameters in critically ill patients with COVID-19. Methods: Aprospective analytical study in which 37 critically ill volunteers between 41 and 71 years of age withCOVID-19 were evaluated at baseline and three days of intensive care unit (ICU) stay. 25-OH-D3 and25-OH-D2 were analyzed by liquid chromatography–tandem mass spectrometry and total 25-OH-Dlevels were calculated as the sum of both. Results: All patients presented low 25-OH-D levels atbaseline, decreasing total 25-OH-D (p = 0.011) mainly through 25-OH-D2(p = 0.006) levels duringICU stay. 25-OH-D2levels decreased a mean of 41.6% ± 89.6% versus 7.0% ± 23.4% for the 25-OH-D3form during the ICU stay. Patients who did not need invasive mechanical ventilation presentedhigher levels of 25-OH-D2 at baseline and follow-up. Lower 25-OH-D and 25-OH-D3levels wereassociated with higher D-dimer at baseline (p = 0.003; p = 0.001) and at follow up (p = 0.029), higherprocalcitonin levels (p = 0.002; p = 0.018) at follow up, and lower percentage lymphocyte counts(p = 0.044; p = 0.040) during ICU stay. Conclusions: Deficient vitamin D status in critical patientswas established at the admission and further worsened after three days of stay. Lower vitamin Dlevels were related to key altered clinical and biochemical parameters on patients with SARS-CoV-2infection. Given the different response of the 25-OH-D3 and 25-OH-D2forms, it would be useful tomonitor them on the evolution of the critically ill patient
PB MDPI
SN 2072-6643 (electrónico)
YR 2021
FD 2021
LK http://hdl.handle.net/10272/20052
UL http://hdl.handle.net/10272/20052
LA eng
NO Herrera-Quintana, L., Gamarra-Morales, Y., Vázquez-Lorente, H., Molina-López, J., Castaño-Pérez, J., Machado-Casas, J. F., Coca-Zúñiga, R., Pérez-Villares, J. M., & Planells, E. (2021). Bad Prognosis in Critical Ill Patients with COVID-19 during Short-Term ICU Stay regarding Vitamin D Levels. Nutrients, 13(6), 1988. https://doi.org/10.3390/nu13061988
NO This research received external funding by FIS Projects from Carlos III Health Institute [REF.PI10/1993]. L.H.-Q. and H.V.-L. are under a FPU fellowship from the Spanish Ministry of EducationThanks are due to all the patients who participated in our study and thepersonnel from the Hospital Virgen de las Nieves, and FIBAO foundation (Fundación PúblicaAndaluza para la Investigación Biosanitaria de Andalucía Oriental Alejandro Otero) from Granada.We also acknowledge the expertise of the translator who provided English editing
DS Repositorio Institucional de la Universidad de Huelva
RD 31 may 2026