RT Journal Article
T1 Association between Polyphenol Intake and Gastric Cancer Risk by Anatomic and Histologic Subtypes: MCC-Spain
A1 Rubín García, María
A1 Vitelli Storelli, Facundo
A1 Zamora Ros, Raul
A1 Alguacil Ojeda, Juan
AB Several anticancer properties have been largely attributed to phenolics in in vivo andin vitro studies, but epidemiologic evidence is still scarce. Furthermore, some classes have not beenstudied in relation to gastric cancer (GC). The aim of this study was to assess the relationship betweenthe intake of phenolic acids, stilbenes, and other phenolics and the risk of developing GC and itsanatomical and histological subtypes. We used data from a multi-case-control study (MCC-Spain)obtained from different regions of Spain. We included 2700 controls and 329 GC cases. Oddsratios (ORs) were calculated using mixed effects logistic regression considering quartiles of phenolicintake. Our results showed an inverse association between stilbene and lignan intake and GC risk(ORQ4 vs. Q1 = 0.47; 95% CI: 0.32–0.69 and ORQ4 vs. Q1 = 0.53; 95% CI: 0.36–0.77, respectively). Wefound no overall association between total phenolic acid and other polyphenol class intake and GCrisk. However, hydroxybenzaldehydes (ORQ4 vs. Q1 = 0.41; 95% CI: 0.28–0.61), hydroxycoumarins(ORQ4 vs. Q1 = 0.49; 95% CI: 0.34–0.71), and tyrosols (ORQ4 vs. Q1 = 0.56; 95% CI: 0.39–0.80) wereinversely associated with GC risk. No differences were found in the analysis by anatomical orhistological subtypes. In conclusion, a diet high in stilbenes, lignans, hydroxybenzaldehydes,hydroxycoumarins, and tyrosols was associated with a lower GC risk. Further prospective studiesare needed to confirm our results.
PB MDPI
SN 1134-248X
YR 2020
FD 2020-10
LK http://hdl.handle.net/10272/19006
UL http://hdl.handle.net/10272/19006
LA eng
NO Rubín García, M., Vitelli Storelli, F.,  Zamora Ros, R. ... Alguacil Ojeda, J.  (2020). Association between Polyphenol Intake and Gastric Cancer Risk by Anatomic and Histologic Subtypes: MCC-Spain. Nutrients, 12(11), 3281. DOI: https://doi.org/10.3390/nu12113281
DS Repositorio Institucional de la Universidad de Huelva
RD 15 jun 2026