RT Journal Article
T1 Magnesium supplementation reduces inflammation in rats with induced chronic kidney disease
A1 López Baltanás, Rodrigo
A1 Rodríguez Ortiz, M. Encarnación
A1 Canalejo Raya, Antonio
A1 Almadén, Yolanda
AB BackgroundInflammation is a common feature in chronic kidney disease (CKD) that appears specifically associated with cardiovascular derangements in CKD patients. Observational studies have revealed a link between low Mg levels and inflammation. In this study, we hypothesize that Mg might have a modulatory effect on the inflammation induced under the uraemic milieu.MethodsIn vivo studies were performed in a 5/6 nephrectomized rat model of CKD. Furthermore, a possible direct effect of Mg was addressed through in vitro studies with vascular smooth muscle cells (VSMCs).ResultsUraemic rats fed a normal (0.1%) Mg diet showed a systemic inflammatory response evidenced by the elevation in plasma of the pro‐inflammatory cytokines TNF‐α, IL‐1β and IL‐6, and GPx activity, a marker of oxidative stress. Importantly, an increased expression of these cytokines in the aortic tissue was also observed. In contrast, a dietary Mg supplementation (0.6%) greatly prevented the oxidative stress and the pro‐inflammatory response. In vitro, in VSMCs cultured in a pro‐inflammatory high phosphate medium, incubation with Mg 1.6 mM inhibited the increase in the production of ROS, the rise in the expression of TNF‐α, IL‐1β, IL‐6 and IL‐8 and the activation of NF‐κB signalling that was observed in cells incubated with a normal (0.8 mM) Mg.ConclusionMg supplementation reduced inflammation associated with CKD, exerting a direct effect on vascular cells. These findings support a possible beneficial effect of Mg supplementation along the clinical management of CKD patients.
PB Wiley
SN 1365-2362
YR 2021
FD 2021-04
LK http://hdl.handle.net/10272/19854
UL http://hdl.handle.net/10272/19854
LA eng
NO López Baltanás, R., Rodríguez Ortiz, M. E., Canalejo Raya, A. ... Almadén, Y. (2021). Magnesium supplementation reduces inflammation in rats with induced chronic kidney disease. European Journal of Clinical Investigation. DOI: https://doi.org/10.1111/eci.13561
DS Repositorio Institucional de la Universidad de Huelva
RD 1 jun 2026