RT Journal Article
T1 Alkylphenolic compounds and risk of breast and prostate cancer in the MCCS-Spain study
A1 Peremiquel Trillas, Paula
A1 Alguacil Ojeda, Juan
A1 Costas, Laura
AB BackgroundAlkylphenolic compounds are chemicals with endocrine disrupting properties that have been widely used in industry with important changes in their usage over time. Few epidemiologic studies have evaluated the effect of alkylphenolic compounds on human health.ObjectivesWe investigated whether occupational exposure to alkylphenolic compounds is associated with breast and prostate cancer.MethodsWe carried out a population-based case–control study including 1513 incident cases of breast cancer, 1095 of prostate cancer, and 3055 controls, frequency matched by sex, age and region. Occupational exposure to alkylphenolic compounds was estimated using a recently developed job-exposure matrix, which considered different scenarios of exposure and different subtypes of alkylphenolic compounds.ResultsHistory of occupational exposure to alkylphenolic compounds was modestly associated with breast cancer (OR = 1.23; 95% CI = 1.01–1.48). Within the different scenarios, the occupational use of domestic tensioactives was positively associated with breast cancer (OR = 1.28; 95% CI = 1.02–1.60), while occupational exposure in other scenarios showed mostly a suggestion of a similar positive associations. Exposure to nonylphenol ethoxylates was positively associated with breast cancer (OR = 1.21; 95% CI = 1.00–1.47), while exposure to other compounds was uncommon. In general, we did not observe associations between alkylphenolic compounds and prostate cancer, except for a positive association among men occupationally exposed to cosmetic, hair and personal hygiene products.ConclusionsOur findings suggest a modest association between breast cancer risk and occupational exposure to alkylphenolic compounds, and no associations between these compounds and prostate cancer risk. These findings warrant further corroboration in other studies.
PB Elsevier
SN 0160-4120
YR 2019
FD 2019
LK http://hdl.handle.net/10272/20912
UL http://hdl.handle.net/10272/20912
LA eng
NO Peremiquel-Trillas, P., Benavente, Y., Martín-Bustamante, M., Casabonne, D., Pérez-Gómez, B., Gómez-Acebo, I., Oliete-Canela, A., Diéguez-Rodríguez, M., Tusquets, I., Amiano, P., Mengual, L., Ardanaz, E., Capelo, R., Molina de la Torre, A. J., Salas Trejo, D., Fernández-Tardón, G., Lope, V., Jimenez-Moleon, J. J., Marcos-Gragera, R., … Costas, L. (2019). Alkylphenolic compounds and risk of breast and prostate cancer in the MCC-Spain study. In Environment International (Vol. 122, pp. 389–399). Elsevier BV. https://doi.org/10.1016/j.envint.2018.12.007
NO This work was partially funded by the public grants from theCatalan Government (2014SGR756, 2017SGR1085, 2017SGR733,SLT006/17/76), and European Regional Development Fund-ERDF, bythe “Accion Transversal del Cancer”, approved on the Spanish MinistryCouncil on the 11th October 2007, by the Instituto de Salud Carlos IIIFEDER(PI08/1770, PI08/0533, PI08/1359, PS09/00773-Cantabria,PS09/01286-León, PS09/01903-Valencia, PS09/02078-Huelva, PS09/01662-Granada, PI11/01403, PI11/01889-FEDER, PI11/00226, PI11/01810, PI11/02213, PI12/00488, PI12/00265, PI12/01270, PI12/00715, PI12/00150, PI14/01219, PI14/0613, PI15/00069, PI15/00914, PI15/01032, PI11/01810, PI14/01219, PI11/02213, PIE16/00049, PI17/01179), by the Fundación Marqués de Valdecilla (API 10/09), by the Red Temática de Investigación del Cáncer (RTICC) del ISCIII(RD12/0036/0036), by the Junta de Castilla y León (LE22A10-2), bythe Consejería de Salud of the Junta de Andalucía (PI-0571-2009, PI-0306-2011, salud201200057018tra), by the Conselleria de Sanitat ofthe Generalitat Valenciana (AP_061/10), by the Recercaixa (2010ACUP00310), by the Regional Government of the Basque Country, by theConsejería de Sanidad de la Región de Murcia, by the EuropeanCommission grants FOOD-CT-2006-036224-HIWATE, by the SpanishAssociation Against Cancer (AECC) Scientific Foundation, by theCatalan Government-Agency for Management of University andResearch Grants (AGAUR) grants 2014SGR647 and 2014SGR850.ISGlobal is a member of the CERCA Programme, Generalitat deCatalunya.
DS Repositorio Institucional de la Universidad de Huelva
RD 30 may 2026