RT Journal Article
T1 Association of time of breakfast and nighttime fasting duration with breast cancer risk in the multicase-control study in Spain
A1 Palomar Cros, Anna
A1 Alguacil Ojeda, Juan
A1 Kogevinas, Manolis
AB Circadian nutritional behaviors, defined by the daily eating/fasting cycle, have been linked with breast cancer. This study aimed to further disentangle the association of nighttime fasting duration and time of breakfast with breast cancer risk. We analyzed data from 1,181 breast cancer cases and 1,326 population controls from the Spanish multicase-control study (MCC-Spain), 2008–2013. We collected circadian nutritional behaviors at mid-age via a telephonic interview. We applied logistic regression to estimate odds ratios (OR) and 95% confidence intervals (CIs) for the association of nighttime fasting duration and time of breakfast with breast cancer risk in all women and stratified by menopausal status. Models were adjusted for age, center, education, family history of breast cancer, age at menarche, number of children, breastfeeding, age at first child, body mass index (BMI), contraceptive use, and hormonal replacement therapy (HRT). A later time of breakfast was associated with a non-significant increased risk of breast cancer (OR = 1.05, 95% CI: 0.95–1.16, per hour increase). This association was stronger among premenopausal women, among whom each hour later, the time of breakfast was associated with an 18% increase in breast cancer risk (OR = 1.18, 95% CI: 1.01–1.40). The association was not observed in postmenopausal women. We did not observe an association between nighttime fasting duration and breast cancer risk after adjusting for the time of breakfast. In this study, late breakfast was associated with increased breast cancer risk, especially among premenopausal women, compared with early breakfast. Aside from nutritional quality, circadian nutritional behaviors should be further studied in relation to cancer.
PB Frontiers Media
SN 2296-861X (electrónico)
YR 2022
FD 2022
LK https://hdl.handle.net/10272/21715
UL https://hdl.handle.net/10272/21715
LA eng
NO Palomar-Cros, A., Harding, B. N., Espinosa, A., Papantoniou, K., Pérez-Gómez, B., Straif, K., Ardanaz, E., Fernández Villa, T., Amiano, P., Gómez-Acebo, I., Moreno, V., Alguacil, J., Fernández-Tardón, G., Molina-Barceló, A., Marcos-Gragera, R., Aragonés, N., Castaño-Vinyals, G., Guevara, M., Marcos Delgado, A., … Kogevinas, M. (2022). Association of time of breakfast and nighttime fasting duration with breast cancer risk in the multicase-control study in Spain. In Frontiers in Nutrition (Vol. 9). Frontiers Media SA. https://doi.org/10.3389/fnut.2022.941477
NO This study was partially funded by the “Accion Transversaldel Cancer,” approved on the Spanish Ministry Council onthe 11 October 2007, Instituto de Salud Carlos III-FEDER(PI08/1770, PI08/0533, PI08/1359, PS09/00773, PS09/01286,PS09/01903, PS09/02078, PS09/01662, PI11/01889, PI11/02213,PI12/00488, PI12/01270, PI12/00715, PI14/01219, PI14/0613,and PI17/01388), Fundación Marqués de Valdecilla (API10/09), the ICGC International Cancer Genome ConsortiumCLL [The ICGC CLL-Genome Project was funded bySpanish Ministerio de Economía y Competitividad (MINECO)through the Instituto de Salud Carlos III (ISCIII) and RedTemática de Investigación del Cáncer (RTICC) del ISCIII(RD12/0036/0036)], the Junta de Castilla y León (LE22A10-2), the Consejería de Salud of the Junta de Andalucía(PI-0571-2009, PI-0306-2011, and salud201200057018tra),the Conselleria de Sanitat of the Generalitat Valenciana(AP_061/10), the Recercaixa (2010ACUP 00310), the RegionalGovernment of the Basque Country, the Consejería de Sanidadde la Región de Murcia, by the European Commission grantsFOOD-CT-2006-036224-HIWATE, the Spanish AssociationAgainst Cancer (AECC) Scientific Foundation, by theCatalan Government—Agency for Management of Universityand Research Grants (AGAUR) grants 2017SGR723 and2014SGR850, the Fundación Caja de Ahorros de Asturias, andthe University of Oviedo. ISGlobal acknowledges support from the Spanish Ministry of Science and Innovation through the“Centro de Excelencia Severo Ochoa 2019–2023” Program(CEX2018-000806-S) and support from the Generalitat deCatalunya through the CERCA Program. AP-C was supportedby the MINECO (Ministry of Economy in Spain) Grant no.PRE2019-089038, fellowship.
DS Repositorio Institucional de la Universidad de Huelva
RD 30 may 2026