RT Journal Article
T1 Metallomic Signatures of Lung Cancer and Chronic Obstructive Pulmonary Disease
A1 Callejón Leblic, María Belén
A1 Sánchez Espirilla, Saida
A1 Díaz Olivares, Isabel
A1 Padrón Fraysse, L.A.
A1 Gómez Ariza, José Luis
A1 Pereira Vega, Antonio
A1 García Barrera, Tamara
AB Lung cancer (LC) is the leading cause of cancer deaths, and chronic obstructive pulmonarydisease (COPD) can increase LC risk. Metallomics may provide insights into both of these tobaccorelateddiseases and their shared etiology. We conducted an observational study of 191 human serumsamples, including those of healthy controls, LC patients, COPD patients, and patients with bothCOPD and LC.We found 18 elements (V, Al, As, Mn, Co, Cu, Zn, Cd, Se,W, Mo, Sb, Pb, Tl, Cr, Mg, Ni,and U) in these samples. In addition, we evaluated the elemental profiles of COPD cases of varyingseverity. The ratios and associations between the elements were also studied as possible signaturesof the diseases. COPD severity and LC have a significant impact on the elemental composition ofhuman serum. The severity of COPD was found to reduce the serum concentrations of As, Cd, andTl and increased the serum concentrations of Mn and Sb compared with healthy control samples,while LC was found to increase Al, As, Mn, and Pb concentrations. This study provides new insightsinto the effects of LC and COPD on the human serum elemental profile that will pave the way forthe potential use of elements as biomarkers for diagnosis and prognosis. It also sheds light on thepotential link between the two diseases, i.e., the evolution of COPD to LC.
PB MDPI
SN 1661-6596
SN 1422-0067 (electrónico)
YR 2023
FD 2023-09
LK https://hdl.handle.net/10272/22469
UL https://hdl.handle.net/10272/22469
LA eng
NO Callejón-Leblic, B.; Sánchez Espirilla, S.; Gotera-Rivera, C.; Santana, R.; Díaz-Olivares, I.; Marín, J.M.; Macario, C.C.; Cosio, B.G.; Fuster, A.; García, I.S.; et al. (2023). Metallomic Signatures of Lung Cancer and Chronic Obstructive Pulmonary Disease. In International Journal of Molecular Sciences (Vol. 24, Issue 18, p. 14250). MDPI. https://doi.org/ 10.3390/ijms241814250
NO This work has been supported by the project "Heteroatom-tagged proteomics and metabolomics to study lung cancer. Influence of gut microbiota” (Ref.: PY20_00366) (Project of Excellence, Regional Ministry of Economy, Knowledge, Business and University, Andalusia, Spain). The authors are also grateful for grants 651/2018 and 115/2020 from the Spanish Society of Pneumology and Surgery (SEPAR) and grant 08/2018 from the Association of Pneumologyand Thoracic Surgery (Neumosur), which were used to facilitate recruitment at the hospitals and biobank registration. The authors also thank Instituto de Salud Carlos III (AES16/01783) and wish to express their gratitude for the unrestricted funding from the Menarini Group and AstraZeneca.
DS Repositorio Institucional de la Universidad de Huelva
RD 1 jun 2026