RT Journal Article
T1 Selective C−H Bond Functionalization of Unprotected Indoles by Donor-Acceptor Carbene Insertion
A1 Pizarro Javier, Juan Diego
A1 Morán González, Lucía
A1 González Fernández, Iván
A1 Maseras, Feliu
A1 Romero Fructos-Vázquez, Manuel
A1 Pérez Romero, Pedro José
AB Copper catalysts containing alkoxydiaminophosphine (ADAP) ligand catalyze the selective C3- Hfunctionalization of unprotected indoles upon carbene transfer from donor-acceptor diazo compounds, the N-H bond remaining unaltered during the transformation. Mechanistic studies, including DFT calculations, allows proposing the existence of two competitive pathways, none of them occurring through the formation of cyclopropane intermediates, at variance with previously reported systems.
PB Wiley
SN 1615-4150
SN 1615-4169 (electrónico)
YR 2023
FD 2023-07
LK https://hdl.handle.net/10272/22449
UL https://hdl.handle.net/10272/22449
LA eng
NO Pizarro, J-D., Morán‐González, L., González‐Fernández, I., Maseras, F., Romero-Fructos, M., & Pérez, P. J. (2023). Selective C−H Bond Functionalization of Unprotected Indoles by Donor‐Acceptor Carbene Insertion. In Advanced Synthesis & Catalysis. Wiley. https://doi.org/10.1002/adsc.202300252
NO We thank to Ministerio de Ciencia e Innovación for Grants PID2020-113797RB-C21, PID2020-112825RB-I00 and CEX2019-000925-S. We also thank Junta de Andalucía (P18-1536) and Universidad de Huelva (P. O.Feder UHU-202024). I.-G. F thanks the Investigo Program for a contract. L. M.-G. thanks Generalitat de Catalunya for an FI-Agaur predoctoral contract, 2022FI−B2000621.
DS Repositorio Institucional de la Universidad de Huelva
RD 31 may 2026