RT Journal Article T1 Influence of the Sense of Coherence, the Doctor–Patient Relationship, Optimism and Non-Haematological Adverse Reactions on Health-Related Quality of Life in Patients with Breast Cancer A1 Prieto Callejero, Blanca A1 Andrés Villas, Montserrat A1 Gómez Salgado, Juan A1 Rivera, Francisco AB Breast cancer is the most common malignant tumour in women around the world. Theobjective of this study was to quantify the number of non-haematological adverse reactions associatedwith chemotherapy, as well as to assess the e ect of the sense of coherence, optimism–pessimismand the quality of the doctor–patient relationship on the quality of life of breast cancer patients. Tothis end, a cross-sectional descriptive study was conducted involving 110 breast cancer patientswho were treated with docetaxel, epirubicin, and cyclophosphamide during the period 2012–2014.The di erence in the quality of life in patients who have five or fewer toxicities compared to thosewith more than six is highlighted. This di erence is not as important when comparing patientswith 6 to 10 toxicities and those with more than 10. The multivariate model used in this studycorroborates the direct implication of the sense of coherence on the quality of life and adds thenumber of adverse reactions as a new construct. This has virtually the same impact on the qualityof life of these patients, but in reverse. In conclusion, to improve the quality of life of breast cancerpatients it would be necessary to have an impact on the number of adverse reactions involved inchemotherapeutic treatment, as well as on psychological interventions, with the sense of coherence asa possible starting point. PB MDPI SN 2077-0383 YR 2019 FD 2019-12 LK http://hdl.handle.net/10272/17612 UL http://hdl.handle.net/10272/17612 LA eng NO Prieto Callejero, B., Rivera, F., Andrés Villas, M., Gómez Salgado, J. (2019). Influence of the Sense of Coherence, the Doctor–Patient Relationship, Optimism and Non-Haematological Adverse Reactions on Health-Related Quality of Life in Patients with Breast Cancer. Journal of Clinical Medicine, 8(12), 2043. DOI: https://doi.org/10.3390/jcm8122043 DS Repositorio Institucional de la Universidad de Huelva RD 1 jun 2026