RT Journal Article
T1 Efficiency of IL-6 in Early Prognosis and Follow-Up in Critically Ill Patients with Septic Shock
A1 Gamarra Morales, Yenifer
A1 Molina López, Jorge
A1 Santiago Ruiz, Felipe Carlos
A1 Herrera Quintana, Lourdes
A1 Vázquez Lorente, Héctor
A1 Gascón Luna, Félix
A1 Planells, Elena
AB Background/Objectives: The aim of this study was to investigate the response of interleukin-6 (IL-6) during the first few hours of a patient's stay in the Intensive Care Unit (ICU) in a sample of critically ill patients with septic shock, compared to healthy subjects as controls. Additionally, the study examined the association of IL-6 with morbidity and mortality in these patients, as well as its relationship with biomarkers such as lactic acid, C-reactive protein (CRP) and procalcitonin (PCT). Methods: This was a prospective analytical study involving 28 critically ill patients with septic shock, monitored from ICU admission through to their first three days of stay. Demographic data, comorbidities and clinical information, including IL-6 and severity scores, were recorded. Results: IL-6 levels were significantly higher in patients with septic shock compared to healthy subjects (p < 0.001) upon admission. IL-6 levels decreased by the third day of ICU stay (p < 0.005). An association between IL-6 and mortality was observed (areas under the curve 0.826, confidence interval (CI) 95% 0.659-0.994, p < 0.008). Significant correlations between IL-6 and lactic acid (p < 0.009 and p < 0.018) and partial thromboplastin time (p < 0.004 and p < 0.007) were found on the first and third days, respectively. IL-6 was also the correlated with an anion gap at admission to the ICU (p < 0.009). Conclusions: In conclusion, this study suggests that IL-6 could be a valuable marker for early sepsis follow-up in ICU patients, particularly during the first 72 h of hospitalization, providing important prognostic information in patients with septic shock.
PB MDPI
SN 2079-9721 (electrónico)
YR 2024
FD 2024-11
LK https://hdl.handle.net/10272/25263
UL https://hdl.handle.net/10272/25263
LA eng
NO Gamarra-Morales, Y., Molina-López, J., Santiago-Ruiz, F.-C., Herrera-Quintana, L., Vázquez-Lorente, H., Gascón-Luna, F., & Planells, E. (2024). Efficiency of IL-6 in Early Prognosis and Follow-Up in Critically Ill Patients with Septic Shock. In Diseases (Vol. 12, Issue 11, p. 298). MDPI AG. https://doi.org/10.3390/diseases12110298
NO REF. A-CTS-708-UGR20/European Regional Development Fund (ERDF) "a way of making Europe". Consejería de Transformación Económica, Industria, Conocimiento y Universidades de la Junta de Andalucía.Project FIS PI10/1993/Spanish Carlos III Health Institute
DS Repositorio Institucional de la Universidad de Huelva
RD 30 may 2026