RT Journal Article
T1 Risk factors for atherosclerotic cardiovascular disease in individuals with heterozygous familial hypercholesterolemia: a systematic review and metaanalysis
A1 Mansilla Rodríguez, María Elena
A1 Sánchez Ramos, José Luis
A1 Rigabert Sánchez-Junco, Alina
A1 Pang, Jing
A1 Chan, Dick C
A1 Gutiérrez Cortizo, Eva Nadiejda
A1 Mata, Pedro
A1 Watts, Gerald F
A1 Romero Jiménez, Manuel Jesús
AB Background and aims : Familial hypercholesterolemia (FH) is a highly prevalent monogenic disorder characterized by elevated low-density lipoprotein-cholesterol (LDL-C) levels and premature atherosclerotic cardiovascular disease (ASCVD). The risk factors associated with cardiovascular events in this population vary considerably among studies. This systematic review aims to identify the key risk factors predicting cardiovascular events in patients with a confirmed genetic diagnosis of heterozygous FH (PROSPERO, CRD42022304273).Methods and analysis : Cochrane Library, Embase, MEDLINE, Scopus, UpToDate and other literature databases were searched from inception to June 2023. Records were eligible if they included studies reporting risk factors for ASCVD endpoints in adult patients with a genetic diagnosis of FH. A metaanalysis was performed using MetaEasy.Results : A total of 21 studies were identified, involving 23,613 individual participants and 3489 prevalent cardiovascular events. The sex distribution was 47.2% male and 52.8% female. Most of the studies were conducted in European populations, representing 90.5% of the total. The meta-analysis found associations between ASCVD and hypertension (effect size 0.414; 95% CI: 0.346-0.482), male sex (0.334; 0.213-0.456), smoking (0.324; 0.203-0.445), lipoprotein(a) (0.219; 0.127-0.312), age (0.212; 0.161-0.264), body mass index (0.108; 0.028-0.188), triglycerides (0.084; 0.057-0.111) and LDL-C (0.015; 0.002-0.028).Conclusions : This is the first systematic review and meta-analysis demonstrating that hypertension, male sex, smoking, lipoprotein(a), age, body mass index, triglycerides and LDL-C are significantly and independently associated with ASCVD in genetically confirmed patients with heterozygous FH. These data can inform risk stratification models and optimise therapy in such patients.
PB Elsevier
SN 0021-9150
YR 2026
FD 2026
LK https://hdl.handle.net/10272/28228
UL https://hdl.handle.net/10272/28228
LA eng
NO María Elena Mansilla-Rodríguez, José Luis Sánchez-Ramos, Alina Rigabert Sánchez-Junco, Jing Pang, Dick C. Chan, Eva Nadiejda Gutiérrez-Cortizo, Pedro Mata, Gerald F. Watts, Manuel Jesús Romero-Jiménez, Risk factors for atherosclerotic cardiovascular disease in individuals with heterozygous familial hypercholesterolemia: a systematic review and meta-analysis, Atherosclerosis, Volume 415, 2026, 120650, ISSN 0021-9150, https://doi.org/10.1016/j.atherosclerosis.2026.120650.
NO Funding for the open access charge was provided by the Universidad de Huelva/CBUA.
NO MEMR is the guarantor. MEMR, ARSJ, and MJRJ drafted the manuscript and developed the search strategy. All authors contributed to the development of the selection criteria, the risk of bias assessment strategy, and data extraction criteria. ARSJ, JLSR, and DCF provided statistical expertise. GFW, PM, ENGC, JP, and DCF read and provided feedback. All authors reviewed and approved the final manuscript.
DS Repositorio Institucional de la Universidad de Huelva
RD 30 may 2026