RT Journal Article
T1 Transcriptional and biochemical changes in mouse liver following exposure to a metal/drug cocktail. Attenuating effect of a selenium-enriched diet
A1 Huertas Abril, Paula V.
A1 Prieto Álamo, María José
A1 Jurado Carpio, Juan
A1 Pérez Arévalo, José
A1 Molina Hernández, Verónica
A1 García Barrera, Tamara
A1 Abril, Nieves
AB Real-life pollution usually involves simultaneous co-exposure to different chemicals. Metals and drugs arefrequently and abundantly released into the environment, where they interact and bioaccumulate. Few studiesanalyze potential interactions between metals and pharmaceuticals in these mixtures, although their joint effectscannot be inferred from their individual properties. We have previously demonstrated that the mixture (PC) ofthe metals Cd and Hg, the metalloid As and the pharmaceuticals diclofenac (DCF) and flumequine (FLQ) impairshepatic proteostasis. To gain a deeper vision of how PC affects mouse liver homeostasis, we evaluated here theeffects of PC exposure upon some biochemical and morphometric parameters, and on the transcriptional profilesof selected group of genes. We found that exposure to PC caused oxidative damage that exceeded the antioxidantcapacity of cells. The excessive oxidative stress response resulted in an overabundance of reducing equivalents,which hindered the metabolism and transport of metabolites, including cholesterol and bile acids, between organs.These processes have been linked to metabolic and inflammatory disorders, cancer, and neurodegenerativediseases. Therefore, our findings suggest that unintended exposure to mixtures of environmental pollutants mayunderlie the etiology of many human diseases. Fortunately, we also found that a diet enriched with seleniummitigated the harmful effects of this combination of toxicants.
PB Elsevier
SN 0278-6915
SN 1873-6351 (electrónico)
YR 2024
FD 2024-06
LK https://hdl.handle.net/10272/24674
UL https://hdl.handle.net/10272/24674
LA eng
NO Huertas-Abril, P. V., Prieto-Álamo, M.-J., Jurado, J., Pérez, J., Molina-Hernández, V., García-Barrera, T., & Abril, N. (2024). Transcriptional and biochemical changes in mouse liver following exposure to a metal/drug cocktail. Attenuating effect of a selenium-enriched diet. In Food and Chemical Toxicology (Vol. 191, p. 114845). Elsevier BV. https://doi.org/10.1016/j.fct.2024.114845
NO Projects PG2018-096608-B-C21 and PID2021-123073NB-C21 from the Spanish Ministry of Science and Innovation (MICIN) and Regional Government of Andalusia, group BIO-187. VM-H is supported by the financial fundings of the Regional Government of Andalusia-FEDER (project P18-RTJ-1956).
DS Repositorio Institucional de la Universidad de Huelva
RD 1 jun 2026