RT Journal Article
T1 Exogenous female sex steroids may reduce lung ageing after menopause: A 20-year follow-up study of a general population sample (ECRHS)
A1 Triebner, Kai
A1 Accordini, Simone
A1 Calciano, Lucia
A1 Johannessen, Ane
A1 Benediktsdottir, Bryndis
A1 Bifulco, Ersilia
A1 Demoly, Pascal
A1 Dharmage, Shyamali C.
A1 Franklin, Karl A.
A1 García Aymerich, Judith
A1 Gullón Blanco, José Antonio
A1 Heinrich, Joachim
A1 Holm, Mathias
A1 Jarvis, Debbie
A1 Jogi, Rain
A1 Lindberg, Eva
A1 Martínez-Moratalla Rovira, Jesús
A1 Muniozguren Agirre, Nerea
A1 Pin, Isabelle
A1 Probst-Hensch, Nicole M.
A1 Raherison, Chantal
A1 Sánchez Ramos, José Luis
A1 Schlunssen, Vivi
A1 Svanes, Cecilie
A1 Hustad, Steinar
A1 Leynaert, Bénédicte
A1 Gómez Real, Francisco
AB Objectives: Menopause involves hypoestrogenism, which is associated with numerous detrimental effects, including on respiratory health. Hormone replacement therapy (HRT) is often used to improve symptoms of menopause. The effects of HRT on lung function decline, hence lung ageing, have not yet been investigated despite the recognized effects of HRT on other health outcomes.Study design: The population-based multi-centre European Community Respiratory Health Survey provided complete data for 275 oral HRT users at two time points, who were matched with 383 nonusers and analysed with a two-level linear mixed effects regression model. Main outcome measures: We studied whether HRT use was associated with the annual decline in forced vitalcapacity (FVC) and forced expiratory volume in one second (FEV1). Results: Lung function of women using oral HRT for more than five years declined less rapidly than that of nonusers. The adjusted difference in FVC decline was 5.6 mL/y (95%CI: 1.8 to 9.3, p=0.01) for women who had taken HRT for six to ten years and 8.9 mL/y (3.5 to 14.2, p=0.003) for those who had taken it for more than ten years. The adjusted difference in FEV1 decline was 4.4 mL/y (0.9 to 8.0, p=0.02) with treatment from six to ten years and 5.3 mL/y (0.4 to 10.2, p=0.048) with treatment for over ten years.Conclusions: In this longitudinal population-based study, the decline in lung function was less rapid in women who used HRT, following a dose-response pattern, and consistent when adjusting for potential confounding factors. This may signify that female sex hormones are of importance for lung ageing.
PB Elsevier
SN 0378-5122
YR 2018
FD 2018
LK https://hdl.handle.net/10272/22944
UL https://hdl.handle.net/10272/22944
LA eng
NO Triebner, K., Accordini, S., Calciano, L., Johannessen, A., Benediktsdóttir, B., Bifulco, E., Demoly, P., Dharmage, S. C., Franklin, K. A., Garcia-Aymerich, J., Gullón Blanco, J. A., Heinrich, J., Holm, M., Jarvis, D., Jõgi, R., Lindberg, E., Martínez-Moratalla, J., Muniozguren Agirre, N., Pin, I., … Gómez Real, F. (2019). Exogenous female sex steroids may reduce lung ageing after menopause: A 20-year follow-up study of a general population sample (ECRHS). In Maturitas (Vol. 120, pp. 29–34). Elsevier BV. https://doi.org/10.1016/j.maturitas.2018.11.007
NO Kai Triebner has received a postdoctoral fellowship from the University of Bergen. The present analyses are part of a project funded by the Norwegian Research Council (Project No. 228174) as well as part of the Ageing Lungs in European Cohorts (ALEC) Study (www.alecstudy.org), which has received funding from the European Union's Horizon 2020 research and innovation program (Grant No. 633212). The European Commission supported the European Community Respiratory Health Survey, as part of the “Quality of Life” program. Bodies funding the local studies are listed in the online data supplement.The funding sources had no involvement in the conduct of the research and/or preparation of the article, in study design, in the collection, analysis and interpretation of data, in the writing of the report or in the decision to submit the article for publication.
DS Repositorio Institucional de la Universidad de Huelva
RD 31 may 2026