RT Journal Article
T1 Sleep and breast and prostate cancer risk in the MCC-Spain study
A1 Turner, Michelle C.
A1 Alguacil Ojeda, Juan
A1 Kogevinas, Manolis
AB Breast and prostate cancers have been associated with circadian disruption. Some previous studiesexamined associations of sleep duration and breast or prostate cancer risk though findings remaininconsistent. This study examines associations of a range of detailed sleep characteristics and breastand prostate cancer risk in a large-scale population-based case–control study, MCC-Spain. A totalof 1738 incident breast cancer cases, 1112 prostate cancer cases and frequency matched controls(n = 1910, and 1493 respectively) were recruited. Detailed data on habitual sleep duration, quality,timing, and daytime napping (“siesta”) were collected at recruitment. Additional data on sleep habitsduring both the previous year and at age 40 years were also subsequently captured. Adjusted oddsratios (ORs) and 95% confidence intervals (CI) were estimated. There were no associations of habitualsleep duration (h), timing of sleep, or any or specific sleep problems, and either breast and prostatecancer risk. There was a significant positive association of ever taking habitual siestas at recruitmentand breast cancer risk (OR = 1.22, 95% CI 1.06–1.42), which strengthened with increased frequencyor duration. There were also significant positive associations observed for both breast and prostatecancer, among those reporting recent sleep problems, but not sleep problems at age 40 years, in asubsequent circadian questionnaire. Adverse associations with siesta and disturbed sleep during theprevious year likely reflect symptoms of developing/diagnosed cancer and comorbidities. Overall,there was no clear association between various sleep characteristics and breast or prostate cancer riskobserved.
PB Nature Research
SN 2045-2322 (electrónico)
YR 2022
FD 2022
LK https://hdl.handle.net/10272/22201
UL https://hdl.handle.net/10272/22201
LA eng
NO Turner, M.C., Gracia-Lavedan, E., Papantoniou, K. et al. Sleep and breast and prostate cancer risk in the MCC-Spain study. Sci Rep 12, 21807 (2022). https://doi.org/10.1038/s41598-022-25789-9
DS Repositorio Institucional de la Universidad de Huelva
RD 2 jun 2026