RT Journal Article
T1 A three-generation study on the association of tobacco smoking with asthma
A1 Accordini, Simone
A1 Calciano, Lucia
A1 Johannessen, Ane
A1 Portas, Laura
A1 Benediktsdottir, Bryndis
A1 Bertelsen, Randi Jacobsen
A1 Braback, Lennart
A1 Carsin, Anne-Elie
A1 Dharmage, Shyamali C.
A1 Dratva, Julia
A1 Forsberg, Bertil
A1 Gómez Real, Francisco
A1 Heinrich, Joachim
A1 Holloway, John W.
A1 Holm, Mathias
A1 Janson, Christer
A1 Jogi, Rain
A1 Leynaert, Bénédicte
A1 Malinovski, Andrei
A1 Marcon, Alessandro
A1 Martínez-Moratalla Rovira, Jesús
A1 Raherison, Chantal
A1 Sánchez Ramos, José Luis
A1 Schlunssen, Vivi
A1 Bono, Roberto
A1 Corsico, Angelo Guido
A1 Demoly, Pascal
A1 Dorado Arenas, Sandra
A1 Nowak, Dennis
A1 Pin, Isabelle
A1 Weyler, Joost
A1 Jarvis, Deborah
A1 Svanes, Cecilie
AB Background: Mothers' smoking during pregnancy increases asthma risk in their offspring. There is some evidence that grandmothers' smoking may have a similar effect, and biological plausibility that fathers' smoking during adolescence may influence offspring's health through transmittable epigenetic changes in sperm precursor cells. We evaluated the three-generation associations of tobacco smoking with asthma. Methods: Between 2010 and 2013, at the European Community Respiratory Health Survey III clinical interview, 2233 mothers and 1964 fathers from 26 centres reported whether their offspring (aged </=51 years) had ever had asthma and whether it had coexisted with nasal allergies or not. Mothers and fathers also provided information on their parents' (grandparents) and their own asthma, education and smoking history. Multilevel mediation models within a multicentre three-generation framework were fitted separately within the maternal (4666 offspring) and paternal (4192 offspring) lines. Results: Fathers' smoking before they were 15 [relative risk ratio (RRR) = 1.43, 95% confidence interval (CI): 1.01-2.01] and mothers' smoking during pregnancy (RRR = 1.27, 95% CI: 1.01-1.59) were associated with asthma without nasal allergies in their offspring. Grandmothers' smoking during pregnancy was associated with asthma in their daughters [odds ratio (OR) = 1.55, 95% CI: 1.17-2.06] and with asthma with nasal allergies in their grandchildren within the maternal line (RRR = 1.25, 95% CI: 1.02-1.55). Conclusions: Fathers' smoking during early adolescence and grandmothers' and mothers' smoking during pregnancy may independently increase asthma risk in offspring. Thus, risk factors for asthma should be sought in both parents and before conception.
PB Oxford University Press
SN 0300-5771
SN 1464-3685 (electrónico)
YR 2018
FD 2018
LK https://hdl.handle.net/10272/22937
UL https://hdl.handle.net/10272/22937
LA eng
NO Accordini, S., Calciano, L., Johannessen, A., Portas, L., Benediktsdóttir, B., Bertelsen, R. J., Bråbäck, L., Carsin, A.-E., Dharmage, S. C., Dratva, J., Forsberg, B., Gomez Real, F., Heinrich, J., Holloway, J. W., Holm, M., Janson, C., Jögi, R., Leynaert, B., … Malinovschi, A. (2018). A three-generation study on the association of tobacco smoking with asthma. In International Journal of Epidemiology (Vol. 47, Issue 4, pp. 1106–1117). Oxford University Press (OUP). https://doi.org/10.1093/ije/dyy031
NO The present analyses are part of the Ageing Lungs in European Cohorts (ALEC) Study [www.alecstudy.org], which has received funding from the European Union's Horizon 2020 research and innovation programme under grant agreement No. 633212. The coordination of the European Community Respiratory Health Survey (ECRHS) was supported by the European Commission (phases 1 and 2) and the Medical Research Council (phase 3). Local funding agencies for the ECRHS are reported in the Supplementary Appendix, available as Supplementary data at IJE online.Conflict of interest: J.W.H. reports grants from the European Union’s Horizon 2020 programme (633212), the Medical Research Council UK (MC_PC_15078) and the National Institutes of Health USA (R01 AI091905, R01 AI121226) during the conduct of the study. R.J. reports grants from the Estonian Research Council (personal grant No. 562) during the conduct of the study, grants/grants pending from the Estonian Research Council (personal research grant No. 562), personal fees for consulting and lecturing from GlaxoSmithKline, Boehringer and Novartis and travel/accommodation/meeting expenses paid by GlaxoSmithKline and Boehringer, outside the submitted work. C.R. reports personal fees for consulting and lecturing from ALK, Astra Zeneca, GSK, Boheringer and Novartis, outside the submitted work. A.G.C. reports grants from Chiesi Farmaceutici and GlaxoSmithKline Italy, during the conduct of the study. P.D. reports personal fees for consulting and lecturing from ALK and Stallergenes Greer and personal fees for consulting from Circassia, Chiesi Farmaceutici, ThermofisherScientific and Menarini, outside the submitted work. D.J. reports grants from the Medical Research Council and the European Union’s Horizon 2020 programme, during the conduct of the study. All other authors declare no competing interests.
DS Repositorio Institucional de la Universidad de Huelva
RD 30 may 2026