RT Journal Article
T1 Chitosan-based hydrogels obtained via photoinitiated click polymer IPN reaction
A1 Sánchez Cid, Pablo
A1 Romero, Alberto
A1 Díaz Blanco, Manuel Jesús
A1 Paz Báñez, María Violante de
A1 Pérez Puyana, Víctor
AB Chitosan (CTS) is a polysaccharide with a wide variety of applications in the biomedical field, owing to its outstanding disinfectant properties, biocompatibility and biodegradability, but with limited mechanical properties. The proposed strategy to improve CTS-based hydrogel properties in this study is the formation of a semi-interpenetrating polymer network (semi-IPN). In this way, a photo-initiated radical click reaction was proposed to obtain a synthetic polymer, whose components were included in a CTS solution, resulting in the semi-IPN network after UV illumination. Different crosslinking degrees (CD) and CTS/polymer ratios were evaluated through rheological characterization, along with an assessment of both variables based on an experimental model design, obtaining that, for every CTS/polymer ratio, intermediate values of CD (8 %) offered the best rheological properties. In addition, chemical and microstructural characterization were carried out for selected hydrogels, obtaining consistent results according to rheological characterization, as the 1/1 CTS/polymer ratio with CD 8 % hydrogel displayed the most homogeneous pore size and distribution, consequently leading to the best rheological performance.
PB Elsevier
SN 0167-7322
SN 1873-3166 (electrónico)
YR 2023
FD 2023-03
LK https://hdl.handle.net/10272/22139
UL https://hdl.handle.net/10272/22139
LA eng
NO Sánchez-Cid, P., Romero, A., Díaz, M. J., de-Paz, M. V., & Perez-Puyana, V. (2023). Chitosan-based hydrogels obtained via photoinitiated click polymer IPN reaction. In Journal of Molecular Liquids (Vol. 379, p. 121735). Elsevier BV. https://doi.org/10.1016/j.molliq.2023.121735
NO This study was financially supported by MCIN/AEI/10.13039/5 01100011033/FEDER, UE, through the project PID2021-124294OB-C21. The authors gratefully acknowledge their financial support. This work was also possible thanks to the postdoctoral contract of Víctor M. Pérez Puyana from the ‘‘Contratación de Personal Investigador Doctor” supported by the European Social Fund and Junta de Andalucía (PAIDI DOCTOR – Convocatoria 2019–2020, DOC_00586).
DS Repositorio Institucional de la Universidad de Huelva
RD 30 may 2026