RT Journal Article
T1 Risk factors for cardiovascular events in patients with heterozygous familial hypercholesterolaemia: protocol for a systematic review
A1 Mansilla Rodríguez, María Elena
A1 Romero Jiménez, Manuel Jesús
A1 Rigabert, Alina
A1 Gutiérrez Cortizo, Eva Nadiejda
A1 Sánchez Ramos, José Luis
A1 Mata, Pedro
A1 Pang, Jing
A1 Watts, Gerald F.
AB Introduction: Heterozygous familial hypercholesterolaemia (heFH) is the most common monogenic cause of premature atherosclerotic cardiovascular disease. The precise diagnosis of heFH is established by genetic testing. This systematic review will investigate the risk factors that predict cardiovascular events in patients with a genetic diagnosis of heFH.Methods and analysis: Our literature search will cover publications from database inception until June 2023. We will undertake a search of CINAHL (trial), clinicalKey, Cochrane Library, DynaMed, Embase, Espacenet, Experiments (trial), Fisterra, ÍnDICEs CSIC, LILACS, LISTA, Medline, Micromedex, NEJM Resident 360, OpenDissertations, PEDro, Trip Database, PubPsych, Scopus, TESEO, UpToDate, Web of Science and the grey literature for eligible studies. We will screen the title, abstract and full-text papers for potential inclusion and assess the risk of bias. We will employ the Cochrane tool for randomised controlled trials and non-randomised clinical studies and the Newcastle–Ottawa Scale for assessing the risk of bias in observational studies. We will include full-text peer-reviewed publications, reports of a cohort/registry, case–control and cross-sectional studies, case report/series and surveys related to adults (≥18 years of age) with a genetic diagnostic heFH. The language of the searched studies will be restricted to English or Spanish. The Grading of Recommendations, Assessment, Development and Evaluation approach will be used to assess the quality of the evidence. Based on the data available, the authors will determine whether the data can be pooled in meta-analyses.Ethics and dissemination: All data will be extracted from published literature. Hence, ethical approval and patient informed consent are not required. The findings of the systematic review will be submitted for publication in a peer-reviewed journal and presentation at international conferences.
PB BJM
SN 2044-6055 (electrónico)
YR 2023
FD 2023-07
LK https://hdl.handle.net/10272/22482
UL https://hdl.handle.net/10272/22482
LA eng
NO Mansilla-Rodríguez, M. E., Romero-Jimenez, M. J., Rigabert Sánchez-Junco, A., Gutierrez-Cortizo, E. N., Sánchez-Ramos, J. L., Mata, P., Pang, J., & Watts, G. F. (2023). Risk factors for cardiovascular events in patients with heterozygous familial hypercholesterolaemia: protocol for a systematic review. In BMJ Open (Vol. 13, Issue 3, p. e065551). BMJ. https://doi.org/10.1136/bmjopen-2022-065551
DS Repositorio Institucional de la Universidad de Huelva
RD 1 jun 2026