RT Journal Article T1 Isolated Exercise Interventions for Acute Low Back Pain: Systematic Review and Meta-Analysis of Randomized Controlled Trials A1 Cardellat González, Melania A1 González Gómez, Luis A1 Guzmán Gómez, Juan David A1 Blanco Heras, Laura A1 Arana Rodríguez, Andrés A1 Rodríguez Domínguez, Álvaro José AB Background: Therapeutic exercise (TE) is recommended as the first line of treatment for low back pain (LBP), but questions remain about the true efficacy of TE in the acute phase. This study aimed to evaluate the effectiveness of isolated TE in reducing pain intensity and disability in patients with acute or subacute LBP. Methods: A systematic review with meta-analysis was conducted following the PRISMA guidelines. Randomized controlled trials (RCTs) that analyzed therapeutic exercise alone in one of the intervention groups and assessed pain intensity and disability were included; both outcomes were considered primary in this review. The quality of evidence was assessed using the GRADE tool. Results: Five RCTs were included. Meta-analyses were performed in subgroups according to the comparators: usual care, education, manual therapy, and bed rest. Statistically significant differences in favor of TE were found only when compared to usual care (SMD = −0.23; 95% CI [−0.45, −0.01]; p = 0.04). Conclusions: TE, when prescribed as an isolated intervention, appears to be more effective than usual care in improving short-term disability outcomes in patients with acute LBP. However, the limited quality and number of available studies, together with the typically favorable natural course of acute LBP, suggest that these findings should be interpreted with caution. Current evidence supports the integration of exercise within a comprehensive, multimodal management plan that addresses the physical, psychological, and social dimensions of pain. PB MDPI SN 2227-9032 (electrónico) YR 2025 FD 2025-09 LK https://hdl.handle.net/10272/27160 UL https://hdl.handle.net/10272/27160 LA eng NO Cardellat-González, M., González-Gómez, L., Guzmán-Gómez, J.-D., Blanco-Heras, L., Arana-Rodríguez, A., & Rodríguez-Domínguez, Á.-J. (2025). Isolated Exercise Interventions for Acute Low Back Pain: Systematic Review and Meta-Analysis of Randomized Controlled Trials. Healthcare, 13(17), 2209. https://doi.org/10.3390/healthcare13172209 DS Repositorio Institucional de la Universidad de Huelva RD 30 may 2026