RT Journal Article
T1 Iron Metabolism in Obesity and Metabolic Syndrome
A1 González Domínguez, Álvaro
A1 González Domínguez, Raúl
A1 Visiedo García, Francisco
A1 Lechuga Sancho, Alfonso María
AB Obesity is an excessive adipose tissue accumulation that may have detrimental effectson health. Particularly, childhood obesity has become one of the main public health problemsin the 21st century, since its prevalence has widely increased in recent years. Childhood obesityis intimately related to the development of several comorbidities such as nonalcoholic fatty liverdisease, dyslipidemia, type 2 diabetes mellitus, non-congenital cardiovascular disease, chronicinflammation and anemia, among others. Within this tangled interplay between these comorbiditiesand associated pathological conditions, obesity has been closely linked to important perturbations iniron metabolism. Iron is the second most abundant metal on Earth, but its bioavailability is hamperedby its ability to form highly insoluble oxides, with iron deficiency being the most common nutritionaldisorder. Although every living organism requires iron, it may also cause toxic oxygen damage bygenerating oxygen free radicals through the Fenton reaction. Thus, iron homeostasis and metabolismmust be tightly regulated in humans at every level (i.e., absorption, storage, transport, recycling).Dysregulation of any step involved in iron metabolism may lead to iron deficiencies and, eventually,to the anemic state related to obesity. In this review article, we summarize the existent evidence onthe role of the most recently described components of iron metabolism and their alterations in obesity.
PB MDPI
SN 1422-0067
YR 2020
FD 2020-08
LK http://hdl.handle.net/10272/18878
UL http://hdl.handle.net/10272/18878
LA eng
NO González Domínguez, Á., Visiedo García, F. M., González Domínguez, R. ... Lechuga Sancho, A. M. (2020). Iron Metabolism in Obesity and Metabolic Syndrome. International Journal of Molecular Sciences, 21(15), 5529. DOI: https://doi.org/10.3390/ijms21155529
DS Repositorio Institucional de la Universidad de Huelva
RD 1 jun 2026