@article{10272/22612,
year = {2023},
month = {10},
url = {https://hdl.handle.net/10272/22612},
abstract = {Lung cancer (LC) is a leading cause of mortality, claiming more than 1.8 million deaths per year worldwide. Surgery is one of the most effective treatments when the disease is in its early stages. The study of metabolic alterations after surgical intervention with curative intent could be used to assess the response to treatment or the detection of cancer recurrence. In this study, we have evaluated the metabolomic profile of serum samples (n = 110) from preoperative (PRE) and postoperative (POST) LC patients collected at two different time points (1 month, A; 3-6 months, B) with respect to healthy people. An untargeted metabolomic platform based on reversed phase (RP) and hydrophilic interaction chromatography (HILIC), using ultra-high performance liquid chromatography (UHPLC) and mass spectrometry (MS), was applied (MassIVE ID MSV000092213). Twenty-two altered metabolites were annotated by comparing all the different studied groups. DG(14,0/22:1), stearamide, proline, and E,e-carotene-3,3 '-dione were found altered in PRE, and their levels returned to those of a baseline control group 3-6 months after surgery. Furthermore, 3-galactosyllactose levels remained altered after intervention in some patients. This study provides unique insights into the metabolic profiles of LC patients after surgery at two different time points by combining complementary analytical methods},
organization = {This work has been supported by the project “Heteroatom-tagged proteomics and metabolomics to study LC. Influence of gut microbiota' (Ref.: PY20_00366). Project of Excellence. Regional Ministry of Economy, Knowledge, Business and University, Andalusia, Spain. The authors also thank the grants Ref. 651/2018 and 115/2020 from the Spanish Society of Pneumology and Surgery (SEPAR) and 08/2018 from the Association of Pneumology and Thoracic Surgery (Neumosur) that supported sample recruitment at the hospitals and biobank registration. The authors also thank the Instituto de Salud Carlos III (AES16/01783) and unrestricted funding from the Menarini Group. Funding for open access charge: Universidad de Huelva/CBUA},
publisher = {American Chemical Society},
title = {Untargeted Metabolomic Study of Lung Cancer Patients after Surgery with Curative Intent},
doi = {10.1021/acs.jproteome.3c00356},
author = {Sánchez Espirilla, Saida and Pereira Vega, Antonio and Callejón Leblic, María Belén and Díaz Olivares, Isabel and Gómez Ariza, José Luis and García Barrera, Tamara},
}