RT Journal Article T1 Exploring the association between circulating trace elements, metabolic risk factors, and the adherence to a Mediterranean diet among children and adolescents with obesity A1 González Domínguez, Álvaro A1 Domínguez Riscart, Jesús A1 Millán Martínez, María A1 Lechuga Sancho, Alfonso María A1 González Domínguez, Raúl AB Diet is one of the most important modifiable lifestyle factors for preventing andtreating obesity. In this respect, the Mediterranean diet (MD) has proven to be arich source of a myriad of micronutrients with positive repercussions on humanhealth. Herein, we studied an observational cohort of children and adolescents withobesity (N = 26) to explore the association between circulating blood trace elementsand the degree of MD adherence, as assessed through the KIDMED questionnaire.Participants with higher MD adherence showed better glycemic/insulinemic controland a healthier lipid profile, as well as raised plasma levels of selenium, zinc,cobalt, molybdenum, and arsenic, and increased erythroid content of selenium.Interestingly, we found that these MD-related mineral alterations were closelycorrelated with the characteristic metabolic complications behind childhood obesity,namely hyperglycemia, hyperinsulinemia, and dyslipidemia (p < 0.05, |r| > 0.35).These findings highlight the pivotal role that dietary trace elements may play in thepathogenesis of obesity and related disorders. PB Frontiers Media SN 2296-2565 (electrónico) YR 2023 FD 2023-01 LK https://hdl.handle.net/10272/22273 UL https://hdl.handle.net/10272/22273 LA eng NO González-Domínguez, Á., Domínguez-Riscart, J., Millán-Martínez, M., Lechuga-Sancho, A. M., & González-Domínguez, R. (2023). Exploring the association between circulating trace elements, metabolic risk factors, and the adherence to a Mediterranean diet among children and adolescents with obesity. In Frontiers in Public Health (Vol. 10). Frontiers Media SA. https://doi.org/10.3389/fpubh.2022.1016819 NO This research was partially funded by the Spanish Government through Instituto de Salud Carlos III- (PI22/01899). ÁG-Dwas supported by an intramural grant from the Biomedical Research and Innovation Institute of Cádiz (LII19/16INCO24),and RG-D was recipient of a “Miguel Servet” fellowship (CP21/00120) funded by Instituto de Salud Carlos III. DS Repositorio Institucional de la Universidad de Huelva RD 31 may 2026