@article{10272/20143,
year = {2021},
month = {5},
url = {http://hdl.handle.net/10272/20143},
abstract = {The functionalization of C-H bonds in light alkanes, particularly to form C-N bonds, remains a challenge. We report the dehydrogenative coupling of amides with C1–C4 hydrocarbons to form N-alkyl amide products with tBuOOtBu as oxidant, and a copper complex of a phenanthroline-type ligand as catalyst. The reactions occurred in good yields in benzene or supercritical carbon dioxide as solvents. This strategy allowed for the determination of the relative reactivity of these alkane C-H bonds toward this amination process and showed, in contrast to prior work with larger alkanes, that the reactivity correlated with bond dissociation energies.},
organization = {Support for this work was provided by the MINECO
(CTQ2017-82893-C2-1-R), Junta de Andalucía (P18-RT-1536) and PO FEDER 2014–2020 (UHU-1260216). Work at
UCB was supported by the Director, Office of Science, of the
US Department of Energy under contract no. DE-AC02-
05CH11231. M.A.F. thanks MINECO for a Juan de la Cierva
Incorporación fellowship. Funding for open access charges is
given by Universidad de Huelva/ CBUA.},
publisher = {Wiley},
title = {Copper-Catalyzed Dehydrogenative Amidation of Light Alkanes},
doi = {10.1002/anie.202104737},
author = {Fuentes Domínguez, María Ángeles and Gava, Riccardo and Saper, Noam I. and Romero, Erik A. and Caballero Bevia, Ana and Hartwig, John F. and Pérez Romero, Pedro José},
}