RT Journal Article
T1 Copper-Catalyzed Dehydrogenative Amidation of Light Alkanes
A1 Fuentes Domínguez, María Ángeles
A1 Gava, Riccardo
A1 Saper, Noam I.
A1 Romero, Erik A.
A1 Caballero Bevia, Ana
A1 Hartwig, John F.
A1 Pérez Romero, Pedro José
AB The functionalization of C-H bonds in light alkanes, particularly to form C-N bonds, remains a challenge. We report the dehydrogenative coupling of amides with C1–C4 hydrocarbons to form N-alkyl amide products with tBuOOtBu as oxidant, and a copper complex of a phenanthroline-type ligand as catalyst. The reactions occurred in good yields in benzene or supercritical carbon dioxide as solvents. This strategy allowed for the determination of the relative reactivity of these alkane C-H bonds toward this amination process and showed, in contrast to prior work with larger alkanes, that the reactivity correlated with bond dissociation energies.
PB Wiley
SN 0044-8249
SN 1521-3757 (electrónico)
YR 2021
FD 2021-05
LK http://hdl.handle.net/10272/20143
UL http://hdl.handle.net/10272/20143
LA eng
NO Fuentes, M. Á., Gava, R., Saper, N. I., Romero, E. A., Caballero, A., Hartwig, J. F., & Pérez, P. J. (2021). Copper‐Catalyzed Dehydrogenative Amidation of Light Alkanes. Angewandte Chemie International Edition, 60(34), 18467–18471. https://doi.org/10.1002/anie.202104737
NO Support for this work was provided by the MINECO(CTQ2017-82893-C2-1-R), Junta de Andalucía (P18-RT-1536) and PO FEDER 2014–2020 (UHU-1260216). Work atUCB was supported by the Director, Office of Science, of theUS Department of Energy under contract no. DE-AC02-05CH11231. M.A.F. thanks MINECO for a Juan de la CiervaIncorporación fellowship. Funding for open access charges isgiven by Universidad de Huelva/ CBUA.
DS Repositorio Institucional de la Universidad de Huelva
RD 30 may 2026