RT Journal Article T1 Carotenoids from Haloarchaea and Their Potential in Biotechnology A1 Rodrigo Baños, Montserrat A1 Garbayo Nores, Inés A1 Vílchez Lobato, Carlos A1 Bonete, María José A1 Martínez Espinosa, María Rosa AB The production of pigments by halophilic archaea has been analysed during thelast half a century. The main reasons that sustains this research are: (i) many haloarchaealspecies possess high carotenoids production availability; (ii) downstream processes relatedto carotenoid isolation from haloarchaea is relatively quick, easy and cheap; (iii) carotenoidsproduction by haloarchaea can be improved by genetic modification or even by modifyingseveral cultivation aspects such as nutrition, growth pH, temperature, etc.; (iv) carotenoidsare needed to support plant and animal life and human well-being; and (v) carotenoids arecompounds highly demanded by pharmaceutical, cosmetic and food markets. Several studiesabout carotenoid production by haloarchaea have been reported so far, most of them focusedon pigments isolation or carotenoids production under different culture conditions. However,the understanding of carotenoid metabolism, regulation, and roles of carotenoid derivativesin this group of extreme microorganisms remains mostly unrevealed. The uses of thosehaloarchaeal pigments have also been poorly explored. This work summarises what has beendescribed so far about carotenoids production by haloarchaea and their potential uses inbiotechnology and biomedicine. In particular, new scientific evidence of improved carotenoidproduction by one of the better known haloarchaeon (Haloferax mediterranei) is also discussed. PB MDPI SN 1660-3397 YR 2015 FD 2015 LK http://hdl.handle.net/10272/13533 UL http://hdl.handle.net/10272/13533 LA eng NO Rodrigo Baños, M., Garbayo Nores, I., Vílchez Lobato, C., Bonete, M.J., Martínez Espinosa, M.R.: "Carotenoids from Haloarchaea and Their Potential in Biotechnology". Marine Drugs. Vol. 13, págs. 5508-5532, (2015). DOI: 10.3390/md13095508 NO This work was funded by research grant from the MINECO Spain (CTM2013-43147-R). DS Repositorio Institucional de la Universidad de Huelva RD 31 may 2026