RT Journal Article
T1 Standard Non-Personalized Electric Field Modeling of Twenty Typical tDCS Electrode Configurations via the Computational Finite Element Method: Contributions and Limitations of Two Different Approaches
A1 Molero Chamizo, Andrés
A1 Nitsche, Michael A.
A1 Gutiérrez Lérida, Carolina
A1 Salas Sánchez, Ángeles
A1 Martín Riquel, Raquel
A1 Andújar Barroso, Rafael Tomás
A1 Alameda Bailén, José Ramón
A1 García Palomeque, Jesús Carlos
A1 Nathzidy Rivera-Urbina, Guadalupe
AB Transcranial direct current stimulation (tDCS) is a non-invasive brain stimulation procedureto modulate cortical excitability and related brain functions. tDCS can effectively alter multiplebrain functions in healthy humans and is suggested as a therapeutic tool in several neurological andpsychiatric diseases. However, variability of results is an important limitation of this method. Thisvariability may be due to multiple factors, including age, head and brain anatomy (including skull,skin, CSF and meninges), cognitive reserve and baseline performance level, specific task demands,as well as comorbidities in clinical settings. Different electrode montages are a further source ofvariability between tDCS studies. A procedure to estimate the electric field generated by specific tDCSelectrode configurations, which can be helpful to adapt stimulation protocols, is the computational finite element method. This approach is useful to provide a priori modeling of the current spreadand electric field intensity that will be generated according to the implemented electrode montage.Here, we present standard, non-personalized model-based electric field simulations for motor,dorsolateral prefrontal, and posterior parietal cortex stimulation according to twenty typical tDCSelectrode configurations using two different current flow modeling software packages. The resultingsimulated maximum intensity of the electric field, focality, and current spread were similar, butnot identical, between models. The advantages and limitations of both mathematical simulationsof the electric field are presented and discussed systematically, including aspects that, at present,prevent more widespread application of respective simulation approaches in the field of non-invasivebrain stimulation
PB MDPI
SN 2079-7737 (electrónico)
YR 2021
FD 2021
LK http://hdl.handle.net/10272/20295
UL http://hdl.handle.net/10272/20295
LA eng
NO Molero-Chamizo, A., Nitsche, M. A., Gutiérrez Lérida, C., Salas Sánchez, Á., Martín Riquel, R., Andújar Barroso, R. T., Alameda Bailén, J. R., García Palomeque, J. C., & Rivera-Urbina, G. N. (2021). Standard Non-Personalized Electric Field Modeling of Twenty Typical tDCS Electrode Configurations via the Computational Finite Element Method: Contributions and Limitations of Two Different Approaches. In Biology (Vol. 10, Issue 12, p. 1230). MDPI AG. https://doi.org/10.3390/biology10121230
DS Repositorio Institucional de la Universidad de Huelva
RD 1 jun 2026