RT Journal Article
T1 Erythrocyte Zn concentration and antioxidant response after supplementation with Zn in a postmenopausal population. A double-blind randomized trial
A1 Vázquez Lorente, Héctor
A1 Molina López, Jorge
A1 Herrera Quintana, Lourdes
A1 Gamarra Morales, Yenifer
A1 Quintero Osso, Bartolomé
A1 López González, Beatriz
A1 Planells, Elena
AB Background & aims: Menopausal hormonal changes increase the risk of deficiencies of minerals such as zinc (Zn), which could further worsen the decreased antioxidant defense of postmenopausal women. This study assesses the effect of 8 weeks of Zn supplementation upon the antioxidant status and clinical nutritional parameters of a postmenopausal population.Methods: Fifty-one postmenopausal women were divided into two groups: placebo (PbG) and zinc supplementation (ZnG). Mineral status was determined by Flame Atomic Absorption Spectrophotometry (FAAS). Total Antioxidant Capacity (TAC) and Superoxide Dismutase (SOD) were analyzed by kinetic colorimetric methods. Glutathione Peroxidase (GPx) was assessed by an enzymatic immunological method.Results: Poor Zn status was initially observed in erythrocyte samples. Total antioxidant capacity showed a significant correlation (r = 0.730; p < 0.05) to erythrocyte Zn after the intervention (ZnG: r = 0.96; p < 0.001). Moreover, erythrocyte Zn concentration in ZnG was positively correlated to GPx activity after the intervention (r = 0.61; p < 0.01).Conclusions: The postmenopausal women initially presented Zn deficiency, and the status of this mineral improved after the intervention. Zinc supplementation may be an effective approach for correcting the observed deficiencies, enhancing antioxidant defense in this risk population.
PB Elsevier
YR 2022
FD 2022-03-07
LK http://hdl.handle.net/10272/21178
UL http://hdl.handle.net/10272/21178
LA eng
NO Vázquez-Lorente H, Molina-López J, Herrera-Quintana L, Gamarra-Morales Y, Quintero-Osso B, López-González B, Planells E. Erythrocyte Zn concentration and antioxidant response after supplementation with Zn in a postmenopausal population. A double-blind randomized trial. Exp Gerontol. 2022 Jun 1;162:111766. doi: 10.1016/j.exger.2022.111766. Epub 2022 Mar 9. PMID: 35278643.
NO Funding for open access charge: Universidad de Huelva/CBUA.
DS Repositorio Institucional de la Universidad de Huelva
RD 31 may 2026