RT Journal Article
T1 Clinical presentation of young people (10–24 years old) with brain tumors: results from the international MOBI‑Kids study
A1 Zumel Marne, Angela
A1 Alguacil Ojeda, Juan
A1 Cardis, Elisabeth
AB We used data from MOBI-Kids, a 14-country international collaborative case–control study of brain tumors(BTs), to study clinical characteristics of the tumors in older children (10 years or older), adolescents and young adults (upto the age of 24). Information from clinical records was obtained for 899 BT cases, including signs and symptoms, symptom onset,diagnosis date, tumor type and location. Overall, 64% of all tumors were low-grade, 76% were neuroepithelial tumors and 62% gliomas. There were moremales than females among neuroepithelial and embryonal tumor cases, but more females with meningeal tumors. The mostfrequent locations were cerebellum (22%) and frontal (16%) lobe. The most frequent symptom was headaches (60%), overall,as well as for gliomas, embryonal and ‘non-neuroepithelial’ tumors; it was convulsions/seizures for neuroepithelial tumorsother than glioma, and visual signs and symptoms for meningiomas. A cluster analysis showed that headaches and nausea/vomiting was the only combination of symptoms that exceeded a cutof of 50%, with a joint occurrence of 67%. Overall, themedian time from frst symptom to diagnosis was 1.42 months (IQR0.53–4.80); it exceeded 1 year in 12% of cases, thoughno particular symptom was associated with exceptionally long or short delays. This is the largest clinical epidemiology study of BT in young people conducted so far. Many signs and symptoms were identifed, dominated by headaches and nausea/vomiting. Diagnosis was generally rapid but in 12% diagnosticdelay exceeded 1 year with none of the symptoms been associated with a distinctly long time until diagnosis
PB Springer
SN 0167-594X
SN 1573-7373 (electrónico)
YR 2020
FD 2020-03
LK https://hdl.handle.net/10272/23947
UL https://hdl.handle.net/10272/23947
LA eng
NO Zumel-Marne, A., Kundi, M., Castaño-Vinyals, G., Alguacil, J., Petridou, E. T., Georgakis, M. K., Morales-Suárez-Varela, M., Sadetzki, S., Piro, S., Nagrani, R., Filippini, G., Hutter, H.-P., Dikshit, R., Woehrer, A., Maule, M., Weinmann, T., Krewski, D., ′t Mannetje, A., Momoli, F., … Cardis, E. (2020). Clinical presentation of young people (10–24 years old) with brain tumors: results from the international MOBI-Kids study. In Journal of Neuro-Oncology (Vol. 147, Issue 2, pp. 427–440). Springer Science and Business Media LLC. https://doi.org/10.1007/s11060-020-03437-4
NO This work was supported by the MOBI-Kids study and thework in this study was obtained from the European Community’sSeventh Framework Programme under Grant Agreements Number226873—the MOBI-Kids Project—and 603794—the GERoNiMOproject. Additional funds for the coordination of MOBI-Kids wereobtained from the Spanish Ministry of Science and Innovation(MINECO), while complementary funds for the conduct of MOBI-Kidsin Spain were obtained from the Spanish Health Research Fund (FIS)of the National Institute for Health Carlos III. Italian participation ispartially supported by a Ministry of Health grant (RF-2009-1546284).In Canada, funding was provided by a grant from the Canadian Institutes for Health Research under a peer-reviewed university-industrypartnership program that involved the Canadian Wireless Telecommunications Association, who provided technical data on wirelesstelecommunications practices in Canada. The German study centrereceived additional support by the Federal Ofce for Radiation Protection (BfS). Japanese participation in MOBI-Kids was supported by theMinistry of Internal Afairs and Communications. New Zealand participation was supported by Health Research Council and Cure Kids. InFrance, this study received funds from the French National Agency forSanitary Safety of Food, Environment and Labour (ANSES, contractFSRF2008-3), French National Cancer Institute (INCa), Pfzer Foundation and League against cancer. India received funding from Boardof Research in Nuclear Sciences (BRNS). The funding sources had norole in: the study design; the collection, analysis, and interpretation ofdata; the writing of the report; and the decision to submit the articlefor publication
DS Repositorio Institucional de la Universidad de Huelva
RD 31 may 2026