RT Journal Article
T1 Preliminary Assessment of the Protective and Antitumor Effects of Several Phytoene-Containing Bacterial and Microalgal Extracts in Colorectal Cancer
A1 Perazzoli, Gloria
A1 León-Vaz, Antonio
A1 Gómez-Villegas, Patricia
A1 Rengel Domínguez, Rocío
A1 Molina Márquez, Ana María
A1 León Bañares, Rosa María
AB The identification of new functional food constituents is a priority to improve the prognosis and prevention of colorectal cancer (CRC). In this study, several bacterial and algal phytoene-enriched extracts were obtained, and their potential activity against oxidative damage and their ability to inhibit proliferation and cell migration in several human colon-adenocarcinoma-derived cell lines were assessed. The main conclusions indicate that total extracts of Sphingomonas echinoides and Chlorella sorokiniana exhibited the highest protective effect against oxidative damage. All extracts enhanced the activity of detoxifying enzymes, particularly importantly the increase of NAD(P)H:quinone oxidoreductase activity, which reached a value 40% higher than that of untreated control cells upon exposure to Escherichia coli extracts. Staphylococcus haemolyticus and transgenic E. coli extracts significantly arrested the migration capacity of both cell lines, while S. haemolyticus and C. sorokiniana extracts inhibited cell proliferation by 15 to 20% compared to untreated cells. These results point to these extracts as potential antioxidant complements able to protect cells against oxidative damage and with a moderate ability to inhibit the proliferation and migration of CRC tumor cells, paving the way to design functional foods or probiotic formulations with preventive properties against oxidative stress-related diseases, such as cancer, or as starting point for purifying anticancer compounds.
PB MDPI
SN 1420-3049 (electrónico)
YR 2024
FD 2024-10
LK https://hdl.handle.net/10272/24615
UL https://hdl.handle.net/10272/24615
LA eng
NO Perazzoli, G.; Luque, C.; León-Vaz, A.; Gómez-Villegas, P.; Rengel, R.; Molina-Márquez, A.; Morón-Ortiz, Á.; Mapelli-Brahm, P.; Prados, J.; Melguizo, C.; et al. (2024). Preliminary Assessment of the Protective and Antitumor Effects of Several Phytoene-Containing Bacterial and Microalgal Extracts in Colorectal Cancer. Molecules (Vol. 29, Issue 21, p. 5003). https://doi.org/10.3390/ molecules29215003
NO This research was funded by MICIU/AEI/10.13039/501100011033, ERDF/EU (researchgrants PID2022-140995OB-C21 and C22). P.M.-B. was supported by a postdoctoral fellowship fromConsejería de Transformación Económica, Industria, Conocimiento y Universidades de la Junta de Andalucía(PAIDI 2020). A.M.-O. was supported by a grant associated with grant PID2019-110438RB-C21(NEWCARFOODS). A.M.-M., Á.M.-O. and P.M.-B. are members of the Spanish Carotenoid Network(CaRed), grant RED2022-134577-T, funded by MCIN/AEI/10.13039/501100011033 and ERDF/EU.
DS Repositorio Institucional de la Universidad de Huelva
RD 30 may 2026