RT Journal Article
T1 Low serum DHEA-S is associated with impaired lung function in women
A1 Pesce, Giancarlo
A1 Triebner, Kai
A1 Plaat, Diana A. van der
A1 Sánchez Ramos, José Luis
AB Background: Emerging evidence suggests that androgens and estrogens have a role in respiratory health, butit is largely unknown whether levels of these hormones can affect lung function in adults from the generalpopulation. This study investigated whether serum dehydroepiandrosterone sulfate (DHEA-S), a key precursorof both androgens and estrogens in peripheral tissues, was related to lung function in adult women participatingin the European Community Respiratory Health Survey (ECRHS).Methods: Lung function and serum DHEA-S concentrations were measured in n = 2,045 and n = 1,725 womenin 1999 2002 and in 2010 2013, respectively. Cross-sectional associations of DHEA-S levels (expressed asage-adjusted z-score) with spirometric outcomes were investigated, adjusting for smoking habits, body massindex, menopausal status, and use of corticosteroids. Longitudinal associations of DHEA-S levels in1999 2002 with incidence of restrictive pattern and airflow limitation in 2010 2013 were also assessed.Findings: Women with low DHEA-S (z-score<-1) had lower FEV1 (% of predicted, adjusted difference: -2.2;95%CI: -3.5 to -0.9) and FVC (-1.7; 95%CI: -2.9 to -0.5) and were at a greater risk of having airflow limitationand restrictive pattern on spirometry than women with higher DHEA-S levels. In longitudinal analyses, lowDHEA-S at baseline was associated with a greater incidence of airflow limitation after an 11-years follow-up(incidence rate ratio, 3.43; 95%CI: 1.91 to 6.14).Interpretation: Low DHEA-S levels in women were associated with impaired lung function and a greater riskof developing airflow limitation later in adult life. Our findings provide new evidence supporting a role ofDHEA-S in respiratory health.
PB Elsevier
SN 2589-5370
YR 2020
FD 2020-06
LK http://hdl.handle.net/10272/19945
UL http://hdl.handle.net/10272/19945
LA eng
NO Pesce, G., Triebner, K., Plaat, D. A.  ... Sanchez Ramos, J. L. (2020). Low serum DHEA-S is associated with impaired lung function in women. EClinicalMedicine, 23, 100389. DOI: https://doi.org/10.1016/j.eclinm.2020.100389
DS Repositorio Institucional de la Universidad de Huelva
RD 29 may 2026