@article{10272/28062,
year = {2026},
url = {https://hdl.handle.net/10272/28062},
abstract = {Background: Bone tissue engineering has emerged as a promising technique for treating bone defects in large bones. Recent methods have enabled scaffold designs based on pre-defined microstructures or mechanical behavior patterns, including porosity-graded scaf-folds adaptable to heterogeneous load states. However, there is no consensus on the opti-mal scaffold design strategy, which is sometimes chosen  based on the intact bone or re-sults from computational or in vivo experiments. Objective: This work proposes the de-sign of graded-porosity triply periodic minimal surface (TPMS) scaffolds that mimic the mechanical environment within a bone transport callus at the peak of bone tissue produc-tion, according to in vivo load measurements. Methods: Finite element models based on computational tomography scans were used to define the strain field of the callus at the peak of bone tissue production. The developed scaffold models were evaluated through finite element simulation. Results: The callus simulations reported that the period in which maximum woven bone tissue production was achieved corresponds to the period of maximum axial strain. The graded-porosity scaffolds simulated demonstrated their ability to replicate this strain field along the callus. The microstructural parameters and strain environment of the proposed graded-porosity scaffolds were consistent with find-ing from studies assessing the influence of different microstructural parameters or strain conditions on bone ingrown within scaffolds. Conclusions: The proposed approach—de-signing graded-porosity scaffolds based on the callus strain field at the peak of bone tissue production—proved to be appropriate and may help improve future clinical applications.},
organization = {J.M.-M. is grateful for the support of the MICIU (Ministry of Science, Innovation and Universities of the Spanish Government) and ERPF/EU (European Regional Development Fund of the European Union) via Grant PID 2023-148828OB-I00 funded by MICIU/AEI/10.13039/501100011033 and by the ERDF/EU. J.E.S., A.P.G.C. and P.R.F. are grateful to Fundação para a Ciência e a Tecnologia (FCT), Portugal, for its financial support via LAETA (DOI: 10.54499/UID/50022/2025). J.E.S. also acknowledges FCT for the PhD grant UI/BD/150995/2021. Finally, A.P.G.C. and P.R.F. declare that this article is partly based upon work from COST Action EuroCurvoBioNet CA22153, supported by COST (European Cooperation in Science and Technology).},
publisher = {MDPI},
title = {Optimizing Graded Porous Scaffolds for Bone Defects: Insights from In Vivo Mechanical Environments},
doi = {10.3390/prosthesis8030028},
author = {Mora Macías, Juan and Santos, Jorge E. and Castro, André P. G. and Fernandes, Paulo R.},
}