RT Journal Article
T1 Aerobic Intramolecular Carbon-Hydrogen Bond Oxidation  Promoted by Cu(I) Complexes
A1 Álvarez, María
A1 Molina González, Francisco
A1 Romero Fructos-Vázquez, Manuel
A1 Urbano Baena, Juan
A1 Álvarez, Eleuterio
A1 Sodupe, Mariona
A1 Lledós, Agustí
A1 Pérez Romero, Pedro José
AB The oxidation of C–H bonds by copper centres in enzymes with molecular oxygen takes place in nature under ambient conditions. Herein we report a similar transformation in which under ambient pressure and temperature (1 atm, 25 °C) the complex TpMsCu(THF) (TpMs = hydrotris(3-mesityl-pyrazol-1-yl)borate) undergoes the intramolecular oxidation of an alkylic C–H bond with O2, leading to the formation of a trinuclear compound where alkoxy and hydroxyl ligands are bonded to the copper centres, as inferred from X-ray studies. The presence of adventitious Cu(0) derived from the partial decomposition of initial TpMsCu(THF) facilitates the formation of such a trinuclear compound. DFT studies support the reaction taking place through a Cu(III) alkoxy-hydroxyl copper intermediate.
PB Royal Society of Chemistry
SN 1477-9226
SN 1477-9234 (electrónico)
YR 2020
FD 2020-09
LK http://hdl.handle.net/10272/19651
UL http://hdl.handle.net/10272/19651
LA eng
NO Álvarez, M., Molina, F., Fructos, M. R., Urbano, J., Álvarez, E., Sodupe, M., Lledós, A., & Pérez, P. J. (2020). Aerobic intramolecular carbon–hydrogen bond oxidation promoted by Cu(i) complexes. Dalton Transactions, 49(41), 14647–14655. https://doi.org/10.1039/d0dt03198d
NO Support for this work was provided by the MINECO (CTQ2017-82893-C2-1-R CTQ2017-87889-P and CTQ2017-89132-P) and P.O. FEDER 2014-2020, UHU-1260216. MA thanks Ministerio de Economía y Competitividad for an FPI predoctoral fellowship.
DS Repositorio Institucional de la Universidad de Huelva
RD 30 may 2026