RT Journal Article
T1 Possible role of chondroitin sulphate and glucosamine for primary prevention of colorectal cancer. Results from the MCC-Spain study
A1 Ibáñez Sanz, Gemma
A1 Rada Morgades, Ricardo
A1 Moreno, Victor
AB A safe and effective colorectal cancer (CRC) chemoprevention agent remains to be discovered. We aimto evaluate the association between the use of glucosamine and/or chondroitin sulphate and risk ofcolorectal cancer (CRC) in the MCC-Spain study, a case-control study performed in Spain that included2140 cases of CRC and 3950 population controls. Subjects were interviewed on sociodemographicfactors, lifestyle, family and medical history and regular drug use. Adjusted odds ratios and their 95%confidence intervals were estimated. The reported frequency of chondroitin and/or glucosamine usewas 2.03% in controls and 0.89% in cases. Users had a reduced risk of CRC (OR: 0.47; 95% CI: 0.28–0.79),but it was no longer significant when adjusted for NSAID (nonsteroidal anti-inflammatory drugs) use(OR: 0.82; 95% CI: 0.47–1.40). A meta-analysis with previous studies suggested a protective effect, overall and stratified by NSAID use (OR: 0.77; 95% CI: 0.62–0.97). We have not found strong evidenceof an independent preventive effect of CG on CRC in our population because the observed effects of ourstudy could be attributed to NSAIDs concurrent use. These results merit further research due to thesafety profile of these drugs.
PB Nature Research
SN 2045-2322
YR 2018
FD 2018-02
LK http://hdl.handle.net/10272/19108
UL http://hdl.handle.net/10272/19108
LA eng
NO Ibáñez-Sanz, G., Díez-Villanueva, A., Vilorio-Marqués, L., Gracia, E., Aragonés, N., Olmedo-Requena, R., Llorca, J., Vidán, J., Amiano, P., Nos, P., Fernández-Tardón, G., Rada, R., Chirlaque, M. D., Guinó, E., Dávila-Batista, V., Castaño-Vinyals, G., Pérez-Gómez, B., Mirón-Pozo, B., Dierssen-Sotos, T., … Moreno, V. (2018). Possible role of chondroitin sulphate and glucosamine for primary prevention of colorectal cancer. Results from the MCC-Spain study. Scientific Reports, 8(1). https://doi.org/10.1038/s41598-018-20349-6
DS Repositorio Institucional de la Universidad de Huelva
RD 29 may 2026